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首页> 外文期刊>Infection and immunity >Cross-Reactivity between the Rheumatoid Arthritis-Associated Motif EQKRAA and Structurally Related Sequences Found inProteus mirabilis
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Cross-Reactivity between the Rheumatoid Arthritis-Associated Motif EQKRAA and Structurally Related Sequences Found inProteus mirabilis

机译：类风湿关节炎相关主题EQKRAA与奇异变形杆菌中发现的结构相关序列之间的交叉反应

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Cross-reactivity or molecular mimicry may be one of the underlying mechanisms involved in the etiopathogenesis of rheumatoid arthritis (RA). Antiserum against the RA susceptibility sequence EQKRAA was shown to bind to a similar peptide ESRRAL present in the hemolysin of the gram-negative bacterium Proteus mirabilis, and an anti-ESRRAL serum reacted with EQKRAA. There was no reactivity with either anti-EQKRAA or anti-ESRRAL to a peptide containing the EDERAA sequence which is present in HLA-DRB1?0402, an allele not associated with RA. Furthermore, the EQKRAA and ESRRAL antisera bound to a mouse fibroblast transfectant cell line (Dap.3) expressing HLA-DRB1?0401 but not to DRB1?0402. However, peptide sequences structurally related to the RA susceptibility motif LEIEKDFTTYGEE (P. mirabilisurease), VEIRAEGNRFTY (collagen type II) and DELSPETSPYVKE (collagen type XI) did not bind significantly to cell lines expressing HLA-DRB1?0401 or HLA-DRB1?0402 compared to the control peptide YASGASGASGAS. It is suggested here that molecular mimicry between HLA alleles associated with RA and P. mirabilis may be relevant in the etiopathogenesis of the disease.
机译：交叉反应或分子模仿可能是类风湿关节炎（RA）的发病机制中涉及的潜在机制之一。已证明，针对RA易感性序列EQKRAA的抗血清与革兰氏阴性细菌 Proteus mirabilis 的溶血素中存在的类似肽ESRRAL结合，并且抗ESRRAL血清与EQKRAA反应。与抗EQKRAA或抗ESRRAL的肽与HLA-DRB1？0402中存在的，包含不与RA相关的等位基因的EDERAA序列的肽无反应。此外，EQKRAA和ESRRAL抗血清与表达HLA-DRB1→0401但不与DRB1→0402的小鼠成纤维细胞转染细胞系（Dap.3）结合。然而，与RA易感性基序LEIEKDFTTYGEE（ P。mirabilis urease），VEIRAEGNRFTY（II型胶原）和DELSPETSPYVKE（XI型胶原）结构相关的肽序列并未与表达HLA-DRB1的细胞系显着结合与对照肽YASGASGASGAS相比，Δ0401或HLA-DRB1Δ0402。在此建议与RA和 P相关的HLA等位基因之间的分子模拟。奇异菌可能与疾病的发病机制有关。

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