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首页> 外文期刊>Infection and immunity >Protective Efficacy of Anti-Helicobacter pylori Immunity following Systemic Immunization of Neonatal Mice
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Protective Efficacy of Anti-Helicobacter pylori Immunity following Systemic Immunization of Neonatal Mice

机译：全身小鼠免疫后抗幽门螺杆菌免疫的保护作用。

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Helicobacter pylori infection of the gastric mucosa is a significant cause of morbidity and mortality because of its etiologic role in symptomatic gastritis, peptic ulcer disease, and gastric adenocarcinoma. Infection occurs in young children; therefore, a prophylactic vaccine would have to be administered within the first year of life, a period thought to be immunologically privileged. We investigated vaccine formulations administered by different routes to confer protective anti-H. pylori immunity in neonatal mice. Neonatal mice immunized with a single dose of vaccine in complete Freund's adjuvant (CFA) generated antigen-specific gamma interferon-, interleukin-2 (IL-2)-, IL-4-, and IL-5-secreting T cells in numbers similar to those in immunized adult mice, while vaccine administered to neonates in incomplete Freund's adjuvant (IFA) induced such cells in reduced numbers compared to those in adult mice. Both IFA and CFA, however, provided partial protection from a challenge with infectious H. pylori when the vaccine was administered subcutaneously. Neonatal immunized mice also had reduced bacterial loads when immunized intraperitoneally with CFA. In all cases, protection was equivalent to that achieved when adult counterparts were immunized. These studies suggest that an efficacious vaccine might be successfully administered to very young children to prevent perinatal infection of H. pylori.
机译：胃粘膜的 Helicobacter pylori 感染是发病和死亡的重要原因，因为其在症状性胃炎，消化性溃疡疾病和胃腺癌中起病因作用。感染发生在幼儿中;因此，预防性疫苗必须在生命的第一年内施用，这一时期被认为具有免疫学上的特权。我们研究了通过不同途径给予保护性抗 H 的疫苗制剂。新生小鼠的 pylori 免疫力。在完全弗氏佐剂（CFA）中用单剂量疫苗免疫的新生小鼠产生的抗原特异性伽马干扰素，白介素2（IL-2），IL-4-和IL-5分泌的T细胞数量相似与免疫成年小鼠相比，用不完全弗氏佐剂（IFA）给新生儿接种的疫苗与成年小鼠相比，诱导这类细胞的数量减少了。但是，IFA和CFA都提供了部分保护，使其免受感染性 H的挑战。皮下注射疫苗时会出现幽门螺杆菌。当用CFA腹膜内免疫时，新生儿免疫小鼠的细菌载量也降低了。在所有情况下，保护都等同于成年同龄人免疫后所获得的保护。这些研究表明，一种有效的疫苗可以成功地用于非常小的儿童，以预防围产期 H 的感染。 pylori 。

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