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Fully Virulent Bacillus anthracis Does Not Require the Immunodominant Protein BclA for Pathogenesis

机译:完全毒力的炭疽芽孢杆菌不需要免疫原性蛋白BclA即可发病。

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摘要

The BclA protein is the immunodominant epitope on the surface of Bacillus anthracis spores; however, its roles in pathogenesis are unclear. We constructed a BclA deletion mutant (bclA) of the fully virulent Ames strain. This derivative retained full virulence in several small-animal models of infection despite the bclA deletion.
机译:BclA蛋白是炭疽芽孢杆菌孢子表面的免疫显性表位。然而,其在发病机理中的作用尚不清楚。我们构建了全毒力Ames菌株的BclA缺失突变体( bclA )。尽管删除了 bclA ,该衍生物仍在几种小动物感染模型中保留了全部毒力。

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