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首页> 外文期刊>Infection and immunity >Helicobacter hepaticus Infection Promotes Colon Tumorigenesis in the BALB/c-Rag2?/? ApcMin/+ Mouse
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Helicobacter hepaticus Infection Promotes Colon Tumorigenesis in the BALB/c-Rag2?/? ApcMin/+ Mouse

机译：肝幽门螺杆菌感染促进BALB /c-Rag2α/β中结肠肿瘤的发生。 ApcMin / +鼠标

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Adenomatous polyposis coli (APC) mutations are linked to human and mouse colorectal cancers. The Apc multiple intestinal neoplasia (Min) mouse mutation causes adenomas to develop throughout the small and large intestines. The BALB-Min (C.B6-ApcMin/+) congenic strain was generated by backcrossing into BALB/c the ApcMin allele from C57BL/6J-ApcMin/+ mice. BALB-Min mice have a low tumor multiplicity (27.4 small intestine tumors/mouse) and a relatively long life span (>1 year) that makes them amenable to long-term studies. To investigate the interplay of the adaptive immune system and intestinal tumorigenesis, the immunodeficient compound mutant strain BALB-RagMin (C.Cg-Rag2?/? ApcMin/+) was generated. BALB-RagMin mice had a significant increase in tumors in the small, but not large, intestine relative to their BALB-Min counterparts (43.0 versus 24.0 tumors/mouse, respectively). The results suggest that the adaptive immune system plays a role in either the elimination or the equilibrium phase of cancer immunoediting in the small intestine in this model. We investigated the effect of the enterohepatic bacterial pathogen Helicobacter hepaticus on liver and intestine tumorigenesis in BALB-RagMin mice. H. hepaticus-infected BALB-RagMin mice developed moderate hepatitis, moderate typhlitis, and mild colitis. There were no differences in small intestine and cecal tumor multiplicity, regionality, or size relative to that in uninfected mice. However, H. hepaticus-infected BALB-RagMin mice had a significant increase in colon tumor incidence relative to uninfected BALB-RagMin mice (23.5% versus 1.7%, respectively). The data suggest that H. hepaticus, which is present in many research colonies, promotes colon tumorigenesis in the BALB-RagMin mouse and that it has the potential to confound colon tumorigenesis studies.
机译：腺瘤性息肉病大肠杆菌（ APC ）突变与人和小鼠大肠癌有关。 Apc 多发性肠肿瘤小鼠突变导致腺瘤遍及小肠和大肠。通过将 Apc回交到BALB / c中，产生了BALB-Min（C.B6- Apc Min / + ）同系菌株来自C57BL / 6J- Apc Min / + 的 Min 等位基因老鼠。 BALB-Min小鼠的肿瘤多发性低（27.4小肠肿瘤/小鼠），并且寿命相对较长（> 1年），因此适合长期研究。为了研究适应性免疫系统与肠道肿瘤发生的相互作用，研究了免疫缺陷型复合突变株BALB-RagMin（C.Cg- Rag2 ？/？ Apc Min / + ）。相对于BALB-Min同类小鼠，BALB-RagMin小鼠的小肠（而非大肠）中的肿瘤显着增加（分别为43.0对24.0个肿瘤/小鼠）。结果表明，在该模型中，适应性免疫系统在小肠癌症免疫编辑的消除阶段或平衡阶段均起作用。我们研究了肝肠细菌病原菌 Helicobacter hepaticus 对BALB-RagMin小鼠肝脏和肠道肿瘤发生的影响。 H。感染了肝的BALB-RagMin小鼠出现中度肝炎，中度伤寒和轻度结肠炎。与未感染小鼠相比，小肠和盲肠肿瘤的多重性，区域性或大小没有差异。但是， H。相对于未感染的BALB-RagMin小鼠，肝感染的BALB-RagMin小鼠的结肠肿瘤发生率显着增加（分别为23.5％和1.7％）。数据表明 H。肝（存在于许多研究菌落中）可促进BALB-RagMin小鼠的结肠癌发生，并且有可能混淆结肠癌发生的研究。

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