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首页> 外文期刊>Infection and immunity >ZapA, a Virulence Factor in a Rat Model of Proteus mirabilis-Induced Acute and Chronic Prostatitis
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ZapA, a Virulence Factor in a Rat Model of Proteus mirabilis-Induced Acute and Chronic Prostatitis

机译：ZapA，在变形杆菌引起的急性和慢性前列腺炎大鼠模型中的一种毒力因子

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摘要

Our knowledge of pathogenesis has benefited from a better understanding of the roles of specific virulence factors in disease. To determine the role of the virulence factor ZapA, a 54-kDa metalloproteinase of Proteus mirabilis, in prostatitis, rats were infected with either wild-type (WT) P. mirabilis or its isogenic ZapA? mutant KW360. The WT produced both acute and chronic prostatitis showing the typical histological progressions that are the hallmarks of these diseases. Infection with the ZapA? mutant, however, resulted in reduced levels of acute prostatitis, as determined from lower levels of tissue damage, bacterial colonization, and inflammation. Further, the ZapA? mutant failed to establish a chronic infection, in that bacteria were cleared from the prostate, inflammation was resolved, and tissue was seen to be healing. Clearance from the prostate was not the result of a reduced capacity of the ZapA? mutant to form biofilms in vitro. These finding clearly define ZapA as an important virulence factor in both acute and chronic bacterial prostatitis.
机译：我们对发病机理的了解得益于对特定毒力因子在疾病中的作用的更好理解。为了确定毒性因子ZapA（一种奇迹变形杆菌的54 kDa金属蛋白酶）在前列腺炎中的作用，将大鼠感染了野生型（WT） P。奇异菌或其同基因ZapA ？突变体KW360。 WT产生急性和慢性前列腺炎，显示出典型的组织学进展，这些是这些疾病的标志。然而，ZapA β突变体的感染导致急性前列腺炎的水平降低，这是由较低水平的组织损伤，细菌定植和炎症确定的。此外，ZapA β突变体不能建立慢性感染，因为细菌从前列腺中清除了，炎症得以解决，并且组织被治愈。从前列腺清除不是ZapA ？突变体体外形成生物膜能力降低的结果。这些发现清楚地将ZapA定义为急性和慢性细菌性前列腺炎的重要毒力因子。

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