...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Infection and immunity >Th2 but Not Th1 Immune Bias Results in Altered Lung Functions in a Murine Model of Pulmonary Cryptococcus neoformans Infection
【24h】

Th2 but Not Th1 Immune Bias Results in Altered Lung Functions in a Murine Model of Pulmonary Cryptococcus neoformans Infection

机译：Th2但不是Th1免疫性偏见导致肺功能新球菌感染小鼠模型中肺功能的改变。

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Changes in airway dynamics have been reported in the rat model of pulmonary cryptococcosis. However, it is not known if Cryptococcus neoformans-induced changes in lung functions are related to the immunophenotype that develops in response to cryptococcal infection in the lungs. In this study we performed a parallel analysis of the immunophenotype and airway resistance (standard resistance of the airways [SRAW]) in BALB/c mice infected with highly virulent C. neoformans strain H99 and moderately virulent strain 52D. H99 infection evoked a Th2 response and was associated with increased SRAW, while the SRAW for 52D infection, which resulted in a predominantly Th1-skewed response, did not differ from the SRAW for uninfected mice. We found that an altered SRAW in mice did not positively or negatively correlate with the pulmonary fungal burden, the magnitude of inflammatory response, the numbers of T cells, eosinophils or eosinophil subsets, neutrophils, or monocytes/macrophages, or the levels of cytokines (interleukin-4 [IL-4], IL-10, gamma interferon, or IL-13) produced by lung leukocytes. However, the level of a systemic Th2 marker, serum immunoglobulin E (IgE), correlated significantly with SRAW, indicating that the changes in lung functions were proportional to the level of Th2 skewing in this model. These data also imply that IgE may contribute to the altered SRAW observed in H99-infected mice. Lung histological analysis revealed severe allergic bronchopulmonary mycosis pathology in H99-infected mice and evidence of protective responses in 52D-infected mice with well-marginalized lesions. Taken together, the data show that C. neoformans can significantly affect airflow physiology, particularly in the context of a Th2 immune response with possible involvement of IgE as an important factor.
机译：据报道，在肺隐球菌病大鼠模型中，气道动力学发生了变化。然而，尚不清楚隐球菌 新福尔摩斯诱导的肺功能变化是否与肺隐球菌感染产生的免疫表型有关。在这项研究中，我们对感染高毒性 C的BALB / c小鼠的免疫表型和气道阻力（气道标准抵抗力[SRAW]）进行了平行分析。新甲型H99毒株和中毒52D毒株。 H99感染引起Th2应答，并与SRAW增加有关，而52D感染的SRAW主要导致Th1偏斜的应答，与未感染的小鼠的SRAW没有区别。我们发现小鼠中SRAW的改变与肺真菌负荷，炎症反应的大小，T细胞，嗜酸性粒细胞或嗜酸性粒细胞亚群，嗜中性粒细胞或单核细胞/巨噬细胞的数量或细胞因子水平没有正相关或负相关（肺白细胞产生的白介素4 [IL-4]，IL-10，γ干扰素或IL-13）。但是，全身性Th2标记物血清免疫球蛋白E（IgE）的水平与SRAW显着相关，表明在该模型中肺功能的变化与Th2偏斜的水平成比例。这些数据还暗示，IgE可能有助于在感染H99的小鼠中观察到SRAW的改变。肺组织学分析显示，在H99感染的小鼠中出现了严重的过敏性支气管肺真菌病病理，并在52D感染且边缘化程度良好的小鼠中出现了保护性反应。两者合计，数据显示 C。新甲虫可以显着影响气流生理，特别是在Th2免疫应答的情况下，IgE可能是重要因素。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号