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首页> 外文期刊>Infection and immunity >Polymeric Linear Peptide Chimeric Vaccine-Induced Antimalaria Immunity Is Associated with Enhanced In Vitro Antigen Loading
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Polymeric Linear Peptide Chimeric Vaccine-Induced Antimalaria Immunity Is Associated with Enhanced In Vitro Antigen Loading

机译：聚合线性肽嵌合疫苗诱导的抗疟疾免疫与增强的体外抗原负荷相关。

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摘要

Immunization of mice with Plasmodium berghei or Plasmodium yoelii synthetic linear peptide chimeras (LPCs) based on the circumsporozoite protein protects against experimental challenge with viable sporozoites. The immunogenicity of LPCs is significantly enhanced by spontaneous polymerization. To better understand the antigenic properties of polymeric antimalarial peptides, we studied the immune responses elicited in mice immunized with a polymer or a monomer of a linear peptide construct specific for P. yoelii and compared the responses of antigen-presenting cells following incubation with both peptide species. Efficient uptake of the polymeric peptide in vitro resulted in higher expression of the coactivation markers CD80, CD40, and CD70 on dendritic cells and higher proinflammatory cytokine production than with the monomeric peptide. Macropinocytosis seems to be the main route used by polymeric peptides internalized by antigen-presenting cells. Spontaneous polymerization of synthetic antimalarial-peptide constructs to target professional antigen-presenting cells shows promise for simple delivery of subunit malaria vaccines.
机译：基于环子孢子蛋白的伯氏疟原虫或约氏疟原虫合成线性肽嵌合体（LPC）免疫小鼠可抵抗活子孢子的实验攻击。 LPC的免疫原性通过自发聚合得到显着增强。为了更好地理解聚合抗疟肽的抗原特性，我们研究了用对 P特异的线性肽构建体的聚合物或单体免疫小鼠后引起的免疫反应。并比较了两种肽种孵育后抗原呈递细胞的反应。与单体肽相比，聚合物肽在体外的有效吸收导致共激活标记CD80，CD40和CD70在树突细胞上的表达更高，促炎细胞因子的产生更高。巨胞饮作用似乎是抗原呈递细胞内在化的聚合肽所使用的主要途径。合成的抗疟疾肽构建体自发聚合以靶向专业抗原呈递细胞，显示了亚单位疟疾疫苗的简单递送前景。

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