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首页> 外文期刊>Infection and immunity >Intestinal Antilectin Immunoglobulin A Antibody Response and Immunity to Entamoeba dispar Infection following Cure of Amebic Liver Abscess
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Intestinal Antilectin Immunoglobulin A Antibody Response and Immunity to Entamoeba dispar Infection following Cure of Amebic Liver Abscess

机译：小肠抗凝素免疫球蛋白A抗体治疗和对阿米巴肝脓肿治愈后对变形虫的免疫

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We followed 93 subjects with amebic liver abscess (ALA) and 963 close associate controls at 3-month intervals for 36 months to characterize intestinal and humoral antibody responses to the amebic galactose-inhibitable lectin and to determine whether immunity developed to Entamoeba histolytica or Entamoeba dispar infection following cure of ALA. We found that ALA subjects had a higher prevalence and level of intestinal antilectin immunoglobulin A (IgA) and serum anti-LC3 (cysteine-rich recombinant lectin protein) IgA and IgG antibodies, P < 0.01 and P < 0.05, respectively, compared to controls. The intestinal antilectin IgA antibody response was sustained over a longer time period in ALA subjects (71.8% remained positive at 18 months and 52.6% at 36 months, P < 0.001 compared to 17.6% and 10.3% of controls, respectively). ALA subjects were highly immune to E. dispar infection throughout the study (0% infected at 6 and 36 months, compared to 6.5% and 4.9% of control subjects, respectively, P < 0.05). Upon entry into the study, 6.3% of ALA subjects were infected with E. histolytica; the incidence of new E. histolytica infections in controls (as determined by culture) was too low (1.4%) to determine whether ALA subjects exhibited immunity to new infections. We found that stool cultures every 3 months markedly underestimated the occurrence of new E. histolytica infections, as 15.3% of controls seroconverted after 12 months of follow-up. Unfortunately, under the field conditions present in Durban, South Africa, enzyme-linked immunosorbent assay for detection of lectin antigen in stool yielded unreliable results. In summary, subjects cured of ALA exhibited sustained mucosal IgA antibody responses to the amebic galactose-inhibitable lectin and a high level of immunity to E. dispar infection. Determination of immunity to E. histolytica following cure of ALA will require the use of more sensitive and reliable diagnostic methods.
机译：我们追踪了93名患有阿米巴肝脓肿（ALA）的患者和963位紧密相关的对照组，每3个月间隔36个月，以表征对阿米巴半乳糖可抑制的凝集素的肠道和体液抗体反应，并确定是否对溶血性阿米巴或 Entamoeba dispar 感染可治愈ALA。我们发现ALA受试者的肠道抗凝集素免疫球蛋白A（IgA）和血清抗LC3（富含半胱氨酸的重组凝集素蛋白）IgA和IgG抗体的患病率和水平较高， P <0.01和 P <0.05，与对照组相比。在ALA受试者中，肠道抗凝素IgA抗体应答持续较长时间（18个月时阳性率为71.8％，36个月时为52.6％， P <0.001，而对照组为17.6％和10.3％ ， 分别）。 ALA受试者对 E具有高度免疫力。在整个研究过程中发生了dispar 感染（0％分别在6和36个月感染，而对照组的分别为6.5％和4.9％， P <0.05）。进入研究后，有6.3％的ALA受试者感染了 E。组织溶菌; 新的 E的发生率。对照中的组织溶菌感染（通过培养确定）太低（1.4％），无法确定ALA受试者是否对新感染表现出免疫力。我们发现，每3个月的粪便培养显着低估了新的 E的发生。随访12个月后，有15.3％的对照者发生了血清溶血性组织感染。不幸的是，在南非德班存在的野外条件下，用于检测粪便中凝集素抗原的酶联免疫吸附法无法获得可靠的结果。总之，治愈ALA的受试者表现出对阿米巴半乳糖可抑制的凝集素的持续粘膜IgA抗体应答和对 E的高水平免疫。分散感染。对 E的免疫力测定。治愈ALA后组织溶菌将需要使用更敏感，更可靠的诊断方法。

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