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首页> 外文期刊>Infection and immunity >Fusobacterium nucleatum Induces Premature and Term Stillbirths in Pregnant Mice: Implication of Oral Bacteria in Preterm Birth
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Fusobacterium nucleatum Induces Premature and Term Stillbirths in Pregnant Mice: Implication of Oral Bacteria in Preterm Birth

机译：核梭菌诱导妊娠小鼠的早产和足月分娩：早产中口服细菌的影响

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Fusobacterium nucleatum is a gram-negative anaerobe ubiquitous to the oral cavity. It is associated with periodontal disease. It is also associated with preterm birth and has been isolated from the amniotic fluid, placenta, and chorioamnionic membranes of women delivering prematurely. Periodontal disease is a newly recognized risk factor for preterm birth. This study examined the possible mechanism underlying the link between these two diseases. F. nucleatum strains isolated from amniotic fluids and placentas along with those isolated from orally related sources invaded both epithelial and endothelial cells. The invasive ability may enable F. nucleatum to colonize and infect the pregnant uterus. Transient bacteremia caused by periodontal infection may facilitate bacterial transmission from the oral cavity to the uterus. To test this hypothesis, we intravenously injected F. nucleatum into pregnant CF-1 mice. The injection resulted in premature delivery, stillbirths, and nonsustained live births. The bacterial infection was restricted inside the uterus, without spreading systemically. F. nucleatum was first detected in the blood vessels in murine placentas. Invasion of the endothelial cells lining the blood vessels was observed. The bacteria then crossed the endothelium, proliferated in surrounding tissues, and finally spread to the amniotic fluid. The pattern of infection paralleled that in humans. This study represents the first evidence that F. nucleatum may be transmitted hematogenously to the placenta and cause adverse pregnancy outcomes. The results strengthen the link between periodontal disease and preterm birth. Our study also indicates that invasion may be an important virulence mechanism for F. nucleatum to infect the placenta.
机译： Fusobacterium nucleatum 是口腔中普遍存在的革兰氏阴性厌氧菌。它与牙周疾病有关。它也与早产有关，并已从早产妇女的羊水，胎盘和绒膜中分离出来。牙周疾病是早产的新公认危险因素。这项研究检查了这两种疾病之间潜在联系的可能机制。 F。从羊水和胎盘分离的核菌株以及从口腔相关来源分离的核菌株均侵袭上皮细胞和内皮细胞。侵袭能力可致使 F。核定植并感染孕妇子宫。由牙周感染引起的暂时性菌血症可促进细菌从口腔向子宫的传播。为了验证这一假设，我们静脉注射了 F。核移植到怀孕的CF-1小鼠体内。注射导致早产，死产和未维持的活产。细菌感染被限制在子宫内，而没有全身传播。 F。首先在鼠胎盘血管中发现了核。观察到血管内衬的内皮细胞的浸润。然后细菌穿过内皮，在周围组织中增殖，最后扩散到羊水中。感染方式与人类相似。这项研究代表了 F的第一个证据。核可能通过血源传播到胎盘，并导致不良的妊娠结局。结果加强了牙周疾病和早产之间的联系。我们的研究还表明，入侵可能是 F的重要毒力机制。核感染胎盘。

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