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首页> 外文期刊>Infection and immunity >Rapid Acquisition of Isolate-Specific Antibodies to Chondroitin Sulfate A-Adherent Plasmodium falciparum Isolates in Ghanaian Primigravidae
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Rapid Acquisition of Isolate-Specific Antibodies to Chondroitin Sulfate A-Adherent Plasmodium falciparum Isolates in Ghanaian Primigravidae

机译：快速获取针对加纳百里香的硫酸软骨素A粘附性恶性疟原虫分离株的特异性抗体。

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摘要

Recent evidence suggests that pregnancy-associated malaria (PAM), associated with maternal anemia and low birth weight, results from preferential sequestration of parasitized red blood cells (pRBC) in the placenta via binding of variant surface antigens (VSA) expressed on the surface of pRBC to chondroitin sulfate A (CSA). The VSA mediating CSA binding (VSACSA) and thus sequestration of pRBC in the placenta are antigenically distinct from those that mediate pRBC sequestration elsewhere in the body, and it has been suggested that VSACSA are relatively conserved and may thus constitute an attractive target for vaccination against PAM. Using flow cytometry, levels of antibody to VSA and VSACSA expressed on the surface of red blood cells infected with Plasmodium falciparum isolates were measured during pregnancy and lactation in Ghanaian primigravid women enrolled in a trial of maternal vitamin A supplementation. Antibody responses to VSACSA were detected within the first trimester of pregnancy and increased with increasing duration of pregnancy, and they seemed to be isolate specific, indicating that different CSA-adherent parasite lines express antigenically distinct VSA and thus may not be as antigenically conserved as has been previously suggested. Levels of anti-VSACSA were not significantly associated with placental malarial infection determined by histology, indicating that primary immune responses to VSACSA may not be sufficient to eradicate placental parasitemia in primigravidae.
机译：最新证据表明，与孕妇贫血和低出生体重相关的妊娠相关疟疾（PAM）是由于胎盘表面表达的变异表面抗原（VSA）结合而优先隔离胎盘中的寄生红细胞（pRBC）导致的。 pRBC为硫酸软骨素A（CSA）。介导CSA结合的VSA（VSA CSA ）以及因此在胎盘中螯合pRBC与在体内其他地方介导pRBC螯合的抗原在抗原上是不同的，并且已经提出VSA CSA < / sub>相对保守，因此可以构成针对PAM的疫苗接种的有吸引力的靶标。使用流式细胞仪，检测了加纳初生孕妇在妊娠和哺乳期间感染了恶性疟原虫分离株的红细胞表面表达的VSA和VSA CSA 的抗体水平在孕妇补充维生素A的试验中。在怀孕的头三个月就检测到了对VSA CSA 的抗体反应，并且随着怀孕时间的延长而增加，并且它们似乎是分离的特异性，表明不同的CSA粘附寄生物系表达抗原性不同的VSA，因此可能不像以前建议的那样保守。组织学确定的抗VSA CSA 水平与胎盘疟疾感染无显着相关性，表明对VSA CSA 的初次免疫应答可能不足以根除胎盘早孕的胎盘寄生虫病。 。

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