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Invasive Phenotype of Candida albicans Affects the Host Proinflammatory Response to Infection

机译：白色念珠菌的侵袭性表型影响宿主对感染的促炎反应

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Candida albicans is a major opportunistic pathogen in immunocompromised patients. Production of proinflammatory cytokines by host cells in response to C. albicans plays a critical role in the activation of immune cells and final clearance of the organism. Invasion of host cells and tissues is considered one of the virulence attributes of this organism. The purpose of this study was to investigate whether the ability of C. albicans to invade host cells and tissues affects the proinflammatory cytokine responses by epithelial and endothelial cells. In this study we used the invasion-deficient RIM101 gene knockout strain DAY25, the highly invasive strain SC5314, and highly invasive RIM101-complemented strain DAY44 to compare the proinflammatory cytokine responses by oral epithelial or endothelial cells. Using a high-throughput approach, we found both qualitative and quantitative differences in the overall inflammatory responses to C. albicans strains with different invasive potentials. Overall, the highly invasive strains triggered higher levels of proinflammatory cytokines in host cells than the invasion-deficient mutant triggered. Significant differences compared to the attenuated mutant were noted in interleukin-1α (IL-1α), IL-6, IL-8, and tumor necrosis factor alpha in epithelial cells and in IL-6, growth-related oncogene, IL-8, monocyte chemoattractant protein 1 (MCP-1), MCP-2, and granulocyte colony-stimulating factor in endothelial cells. Our results indicate that invasion of host cells and tissues by C. albicans enhances the host proinflammatory response to infection.
机译：白色念珠菌是免疫功能低下患者的主要机会病原体。宿主细胞响应 C产生促炎细胞因子。白色念珠菌在免疫细胞的活化和生物的最终清除中起着至关重要的作用。宿主细胞和组织的入侵被认为是这种生物的毒力属性之一。这项研究的目的是调查 C的能力。白色念珠菌侵入宿主细胞和组织会影响上皮细胞和内皮细胞对促炎细胞因子的反应。在这项研究中，我们使用入侵缺陷型 RIM101 基因敲除菌株DAY25，高侵染性菌株SC5314和高侵染性 RIM101 互补菌株DAY44，比较了口腔上皮或内皮细胞。使用高通量方法，我们发现对 C的整体炎症反应在质量和数量上都存在差异。具有不同侵袭潜力的白色念珠菌菌株。总体而言，高侵入性菌株比侵入缺陷型突变体触发的宿主细胞触发更高水平的促炎细胞因子。与减毒突变体相比，上皮细胞中白介素-1α（IL-1α），IL-6，IL-8和肿瘤坏死因子α以及与生长相关的癌基因IL-8，IL-6，内皮细胞中的单核细胞趋化蛋白1（MCP-1），MCP-2和粒细胞集落刺激因子。我们的结果表明 C对宿主细胞和组织的入侵。白色念珠菌增强宿主对感染的促炎反应。

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