Down-Regulation of the kps Region 1 Capsular Assembly Operon following Attachment of Escherichia coli Type 1 Fimbriae to d-Mannose Receptors

William R. Schwan; Michael T. Beck; Scott J. Hultgren; Jerry Pinkner; Nathan L. Woolever; Thomas Larson

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Down-Regulation of the kps Region 1 Capsular Assembly Operon following Attachment of Escherichia coli Type 1 Fimbriae to d-Mannose Receptors

机译：大肠杆菌1型菌毛附着于d-甘露糖受体后，kps 1区囊膜装配操纵子的下调

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A differential-display PCR procedure identified the capsular assembly gene kpsD after Escherichia coli type 1 fimbrial binding to mannose-coated Sepharose beads. Limiting-dilution reverse-transcribed PCRs confirmed down-regulation of the kpsD gene, and Northern blot and lacZ fusion analyses showed down-regulation of the kpsFEDUCS region 1 operon. KpsD protein levels fell, and an agglutination test showed less K capsular antigen on the surface following the bacterial ligand-receptor interaction. These data show that binding of type 1 fimbriae (pili) to d-mannose receptors triggers a cross talk that leads to down-regulation of the capsule assembly region 1 operon in uropathogenic E. coli.

机译：差异展示PCR程序鉴定了大肠杆菌 1型纤维与甘露糖包被的琼脂糖珠结合后的荚膜装配基因 kpsD 。有限稀释逆转录PCR证实了 kpsD 基因的下调，Northern blot和 lacZ 融合分析显示了 kpsFEDUCS 区域1操纵子。 KpsD蛋白水平下降，凝集试验显示细菌配体-受体相互作用后，表面的K荚膜抗原减少。这些数据表明，类型1菌毛（pili）与d-甘露糖受体的结合触发了串扰，导致尿路致病性 E中胶囊装配区1操纵子的下调。大肠杆菌。 展开▼

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《Infection and immunity》 |2005年第2期|共6页

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William R. Schwan; Michael T. Beck; Scott J. Hultgren; Jerry Pinkner; Nathan L. Woolever; Thomas Larson;
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中图分类医学免疫学;

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1. Protection against Escherichia coli-induced urinary tract infections with hybridoma antibodies directed against type 1 fimbriae or complementary D-mannose receptors. [J] . S N Abraham, J P Babu, C S Giampapa, Infection and immunity . 1985,第3期

机译：使用针对1型菌毛或互补D-甘露糖受体的杂交瘤抗体来预防大肠杆菌诱导的尿路感染。

2. Molecular analysis of the cso operon of enterotoxigenic Escherichia coli reveals that CsoA is the adhesin of CS1 fimbriae and that the accessory genes are interchangeable with those of the cfa operon [J] . Marie B. Marron, Cyril J. Smyth Microbiology . 1995,第11期

机译：肠毒素大肠杆菌CSO操纵子的分子分析显示CSOA是CS1 FIMBRIAE的粘附素，并且辅助基因与CFA操纵子的互换互换

3. The Escherichia coli ycbQRST operon encodes fimbriae with laminin-binding and epithelial cell adherence properties in Shiga-toxigenic E. coli 0157:H7 [J] . Partha Samadder, Juan Xicohtencatl-Cortes, Zeus Salda_a, Environmental microbiology . 2009,第7期

机译：大肠埃希氏菌ycbQRST操纵子在志贺毒素大肠杆菌0157：H7中编码具有层粘连蛋白结合和上皮细胞粘附特性的菌毛

4. Assembly Structure of CFA/I Fimbriae from Enterotoxigenic Escherichia coli [C] . Di Xia, Stephen J. Savarino, Esther Bullitt Microscopy and microanalysis.;Microscopy and microanalysis. . -1

机译：产肠毒素大肠杆菌的CFA / I菌毛的组装和结构

5. Regulation of Swarming Motility by Polyamines in Escherichia coli and Enzymatic Assay of D-Mannose from Urine [D] . Mehta, Iti. 2018

机译：从尿液中的大肠杆菌中的多胺调节蜂拥而味和尿液的酶促测定

6. Down-Regulation of the kps Region 1 Capsular Assembly Operon following Attachment of Escherichia coli Type 1 Fimbriae to d-Mannose Receptors [O] . William R. Schwan, Michael T. Beck, Scott J. Hultgren, 2005

机译：大肠杆菌1型菌毛附着于d-甘露糖受体后kps 1区囊膜装配操纵子的下调

7. Down-Regulation of the kps Region 1 Capsular Assembly Operon following Attachment of Escherichia coli Type 1 Fimbriae to d-Mannose Receptors [O] . Schwan, William R., Beck, Michael T., Hultgren, Scott J., 2005

机译：大肠杆菌1型菌毛附着于d-甘露糖受体后，kps 1区囊膜装配操纵子的下调

1. 血管紧张素Ⅱ1型受体拮抗剂抑制动脉损伤后中膜平滑肌细胞血小板源性生长因子的表达及细胞迁徙 [J] . 舒强 ,凌光烈 ,蒋健 . 中国病理生理杂志 . 2007,第008期

2. 突触后RIM1α介导NMDA受体再循环囊泡运输上膜的研究 [A] . 王洁洁 . 2015

1. METHOD OF IDENTIFICATION OF PIGS RESISTANT TO INTESTINAL DISEASES ASSOCIATED WITH ESCHERICHIA COLI, METHOD FOR BREEDING PIGS RESISTANT TO INTESTINAL DISEASES ASSOCIATED WITH ESCHERICHIA COLI, ISOLATED DNA MOLECULE (VARIANTS), MOLECULAR ANALYSIS FOR DETECTION OF ESCHERICHIA COLI F18 RECEPTORS IN PIGS AND SET FOR DETECTION OF ESCHERICHIA COLI F18 RECEPTORS [P] . 外国专利： RU2204609C2 . 2003-05-20

机译：鉴定与大肠埃希氏菌相关的肠道疾病的猪的方法，分离与大肠埃希氏菌相关的肠道疾病的猪的方法，分离的DNA分子（变异体），分子分析以检测大肠埃希氏菌和小肠结肠菌大肠埃希氏菌F18受体

2. PROCESS FOR PREPARING L-THREONINE BY FERMENTATION AND USING THE PRODUCTION STRAIN ESCHERICHIA COLI 472 T-23 97: When preparing threonine by fermentation and using therefor the strain Escherichia coli 472 T-23 being partially dependent on isoleucine, having plasmids carrying a threonine operon and a gene for resistance to penicillin, it is possible to produce in a medium with the isoleucine concentration within the limits ensured by a suitable combination of 3 to 1.0 gram per one liter of corn-steep, molass21: 02570-91 11: 279975 [P] . 外国专利： CZ279974B6 . 1995-09-13

机译：通过发酵制备L-苏氨酸和使用生产菌株的方法大肠杆菌472 T-23 97：当通过发酵制备苏氨酸并使用该菌株时，大肠杆菌472 T-23菌株部分依赖于异亮氨酸，具有携带苏氨酸操纵子的质粒和一个对青霉素具有抗性的基因，可以在培养基中产生异亮氨酸的浓度，该浓度范围为每升玉米糊，糖蜜3到1.0克的适当组合确保的限量21：02570-91 11：279975

3. Method prepares L-threonine production 472 t-23 97 of strain Escherichia coli by fermentation and using this: relying partially on isoleucine when preparing 472 T-23 of L-threonine-producing strain Escherichia coli using therefore fermentation method, resistance with the gene and threonine operon that carry in plasmid is to penicillin, it is possible that generating in medium and isoleucine concentration boundary, appropriately combined the 3 to 1. of guarantee0 gram per liter of corn is precipitous, molass21:02570-91 11:279975 [P] . 外国专利： CZ256991A3 . 1993-03-17

机译：该方法通过发酵制备大肠杆菌的L-苏氨酸产量472 t-23 97，并利用该方法：使用发酵法制备产L-苏氨酸的大肠杆菌472 T-23时部分依赖异亮氨酸，具有该基因的抗性和携带质粒的苏氨酸操纵子对青霉素，有可能在培养基和异亮氨酸的浓度范围内产生，适当地将每升玉米中0克3比1保证混合，molass21：02570-91 11：279975

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Down-Regulation of the kps Region 1 Capsular Assembly Operon following Attachment of Escherichia coli Type 1 Fimbriae to d-Mannose Receptors

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