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首页> 外文期刊>Infection and immunity >The Chemokine CCL2 Is Required for Control of Murine Gastric Salmonella enterica Infection
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The Chemokine CCL2 Is Required for Control of Murine Gastric Salmonella enterica Infection

机译：趋化因子CCL2是控制鼠胃沙门氏菌感染所必需的

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Salmonella enterica is a gram-negative intracellular pathogen that can cause a variety of diseases ranging from gastroenteritis to typhoid fever. The Typhimurium serotype causes gastroenteritis in humans; however, infection of mice results in an enteric fever that resembles human typhoid fever and has been used as a model for typhoid fever. The present study examined the role of the chemokine CCL2 in the control of Salmonella infection. Upon infection with salmonellae, mucosal expression of CCL2 is rapidly up-regulated, followed by systemic expression in the spleen. CCL2?/? mice became moribund earlier and had a higher rate of mortality compared to wild-type C57BL/6 mice. Moreover, CCL2?/? mice had significantly higher levels of bacteria in the liver compared to wild-type controls. Mucosal and serum interleukin-6 and tumor necrosis factor alpha levels were elevated in CCL2?/? mice compared to wild-type mice. In vitro analysis demonstrated that CCL2?/? macrophages infected with salmonellae resulted in dysregulated cytokine production compared to macrophages derived from wild-type mice. These data are the first to directly demonstrate CCL2 as a critical factor for immune responses and survival following S. enterica infection.
机译：沙门氏菌是一种革兰氏阴性细胞内病原体，可引起多种疾病，从肠胃炎到伤寒。鼠伤寒血清型会导致人类肠胃炎。然而，小鼠的感染导致肠炎，其类似于人伤寒，并已被用作伤寒模型。本研究检查了趋化因子CCL2在控制沙门氏菌感染中的作用。沙门氏菌感染后，CCL2的粘膜表达迅速上调，随后在脾脏中全身表达。与野生型C57BL / 6小鼠相比，CCL2 ？/？小鼠更早死亡，死亡率更高。此外，与野生型对照相比，CCL2 α/β小鼠的肝脏中细菌水平明显更高。与野生型小鼠相比，CCL2 ？/？小鼠的粘膜和血清白细胞介素6和肿瘤坏死因子α水平升高。体外分析表明，与源自野生型小鼠的巨噬细胞相比，感染沙门氏菌的CCL2 α/β巨噬细胞导致细胞因子生成失调。这些数据是第一个直接证明CCL2是 S后免疫应答和存活的关键因素的数据。肠感染。

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