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首页> 外文期刊>Infection and immunity >Effects of Pregnancy and Intensity of Plasmodium falciparum Transmission on Immunoglobulin G Subclass Responses to Variant Surface Antigens
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Effects of Pregnancy and Intensity of Plasmodium falciparum Transmission on Immunoglobulin G Subclass Responses to Variant Surface Antigens

机译：妊娠和恶性疟原虫传播强度对免疫球蛋白G亚类对多种表面抗原的反应的影响。

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Placenta-sequestering Plasmodium falciparum involved in the pathogenesis of pregnancy-associated malaria (PAM) in otherwise clinically immune women expresses particular variant surface antigens (VSAPAM) on the surface of infected erythrocytes that differ from VSA found in parasitized nonpregnant individuals (non-PAM type VSA). We studied levels of immunoglobulin G (IgG) and IgG subclasses with specificity for VSAPAM and for non-PAM type VSA in pregnant and nonpregnant women from two sites with different endemicities in Cameroon. We found that VSAPAM-specific responses depended on the pregnancy status, parity, gestational age, and parasite transmission intensity, whereas only the parasite transmission intensity influenced the levels of IgG specific for non-PAM type VSA. For both types of VSA, the responses were dominated by the cytophilic subclass IgG1, followed by IgG3. In pregnant women, the levels of VSAPAM-specific antibodies either were very low or negative or were very high, whereas the levels of the antibodies specific for non-PAM type VSA were uniformly high. Interestingly, the levels of VSAPAM-specific IgG1 increased with increasing gestational age, while the levels of the corresponding IgG3 tended to decrease with increasing gestational age. The IgG subclass responses with specificity for non-PAM type VSA did not vary significantly with gestational age. Taken together, our data indicate that IgG1 and to a lesser extent IgG3 are the main subclasses involved in acquired VSAPAM-specific immunity to pregnancy-associated malaria.
机译：胎盘隔离性恶性疟原虫参与了与怀孕相关的疟疾（PAM）的发病机理，否则在临床上免疫的女性在受感染的表面表达特定的变异表面抗原（VSA PAM ）在寄生的非怀孕个体（非PAM型VSA）中发现的不同于VSA的红细胞。我们研究了喀麦隆两个地方病流行率不同的孕妇和非孕妇中针对VSA PAM 和非PAM型VSA特异性的免疫球蛋白G（IgG）和IgG亚类的水平。我们发现VSA PAM 特异性反应取决于怀孕状态，胎次，胎龄和寄生虫传播强度，而只有寄生虫传播强度影响非PAM型VSA特异性IgG的水平。对于两种类型的VSA，反应都以嗜细胞亚类IgG1为主导，其次是IgG3。在孕妇中，VSA PAM 特异性抗体的水平非常低或阴性或很高，而对非PAM型VSA的特异性抗体水平则一直很高。有趣的是，VSA PAM 特异性IgG1的水平随着胎龄的增加而增加，而相应IgG3的水平却随着胎龄的增加而降低。对非PAM型VSA特异性的IgG亚类应答随胎龄没有明显变化。综上所述，我们的数据表明，IgG1和较小程度的IgG3是获得性VSA PAM 对妊娠相关疟疾的特异性免疫的主要亚类。

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