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首页> 外文期刊>Infection and immunity >Mac-1+ Cells Are the Predominant Subset in the Early Hepatic Lesions of Mice Infected with Francisella tularensis
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Mac-1+ Cells Are the Predominant Subset in the Early Hepatic Lesions of Mice Infected with Francisella tularensis

机译：Mac-1 +细胞是感染弗朗西斯菌的小鼠早期肝病变的主要亚群。

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The cell composition of early hepatic lesions of experimental murine tularemia has not been characterized with specific markers. The appearance of multiple granulomatous-necrotic lesions in the liver correlates with a marked increase in the levels of serum alanine transferase and lactate dehydrogenase. Francisella tularensis, detected by specific antibodies, can be first noted by day 1 and becomes associated with the lesions by 5 days postinoculation. These lesions become necrotic, with some evidence of in situ apoptosis. The lesions do not contain B, T, or NK cells. Rather, the lesions are largely composed of two subpopulations of Mac-1+ cells that are associated with the bacteria. Gr-1+ Mac-1+ immature myeloid cells and major histocompatibility complex class II-positive (MHC-II+) Mac-1+ macrophages were the most abundant cell phenotypes found in the granuloma and are likely major contributors in controlling the infection in its early stages. Our findings have shown that there is an early development of hepatic lesions where F. tularensis colocalizes with both Gr-1+ Mac-1+ and MHC-II+ Mac-1+ cells.
机译：实验性鼠Tularemia的早期肝损伤的细胞组成尚未用特定标记物表征。肝脏中出现多个肉芽肿性坏死病变与血清丙氨酸转移酶和乳酸脱氢酶水平的显着升高有关。由特异抗体检测到的土拉弗朗西斯菌可以在接种后第1天首先注意到，并在接种后5天与病变相关。这些病变变得坏死，有一些原位凋亡的证据。病变不含B，T或NK细胞。而是，病变主要由与细菌相关的Mac-1 + 细胞的两个亚群组成。 Gr-1 + Mac-1 + 未成熟的骨髓细胞和主要组织相容性复合物II类阳性（MHC-II + ）Mac-1 < sup> + 巨噬细胞是肉芽肿中最丰富的细胞表型，可能是早期控制感染的主要因素。我们的研究结果表明， F区域存在肝脏病变的早期发展。 tularensis 与Gr-1 + Mac-1 + 和MHC-II + Mac-1 + < / sup>单元格。

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