Deletion of the Major Proteolytic Site of theHelicobacter pylori Cytotoxin Does Not Influence Toxin Activity but Favors Assembly of the Toxin into Hexameric Structures

Daniela Burroni; Pietro Lupetti; Cristina Pagliaccia; Jean Marc Reyrat; Romano Dallai; Rino Rappuoli; John L. Telford

首页> 外文期刊>Infection and immunity >Deletion of the Major Proteolytic Site of theHelicobacter pylori Cytotoxin Does Not Influence Toxin Activity but Favors Assembly of the Toxin into Hexameric Structures

【24h】

Deletion of the Major Proteolytic Site of theHelicobacter pylori Cytotoxin Does Not Influence Toxin Activity but Favors Assembly of the Toxin into Hexameric Structures

机译：幽门螺杆菌细胞毒素的主要蛋白水解位点的删除不影响毒素活性，但有利于将毒素组装成六聚体结构。

获取原文

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

The Helicobacter pylori cytotoxin is proteolytically cleaved at a flexible hydrophilic loop into two subunits. Deletion of the loop sequences had no effect on biological activity of the toxin in the HeLa cell vacuolation assay but favored the organization of the protein into hexameric rather than heptameric structures.

机译：幽门螺杆菌的细胞毒素在柔性亲水环上被蛋白水解切割为两个亚基。在HeLa细胞空泡试验中，删除环序列对毒素的生物学活性没有影响，但有利于将蛋白质组织成六聚体而不是七聚体结构。

著录项

来源
《Infection and immunity》 |1998年第11期|共4页
作者
Daniela Burroni; Pietro Lupetti; Cristina Pagliaccia; Jean Marc Reyrat; Romano Dallai; Rino Rappuoli; John L. Telford;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种
中图分类医学免疫学;
关键词

相似文献

外文文献
中文文献
专利

1. Direct binding of gangliosides to Helicobacter pylori vacuolating cytotoxin (VacA) neutralizes its toxin activity. [J] . Wada A, Hasegawa M, Wong PF, Glycobiology. . 2010,第6期

机译：神经节苷脂与幽门螺杆菌空泡化细胞毒素（VacA）的直接结合可中和其毒素活性。
2. Direct binding of gangliosides to Helicobacter pylori vacuolating cytotoxin (VacA) neutralizes its toxin activity [J] . Masachika Senba Glycobiology . 2010,第6期

机译：神经节苷脂与幽门螺杆菌空泡化细胞毒素（VacA）的直接结合可中和其毒素活性
3. Helicobacter pylori vacuolating cytotoxin enters cells, localizes to the mitochondria, and induces mitochondrial membrane permeability changes correlated to toxin channel activity [J] . David C. Willhite, Steven R. Blanke Cellular microbiology . 2004,第2期

机译：幽门螺杆菌空泡化细胞毒素进入细胞，定位于线粒体，并诱导与毒素通道活性相关的线粒体膜通透性变化
4. On the structure and assembly of staphylococcal leukocidin: A study of the molecular architecture of β-barrel pore -forming toxins [D] . Miles, George Emmett, Jr. 2005

机译：关于葡萄球菌白细胞介素的结构和组装：β-桶孔形成毒素的分子结构研究
5. Note: Deletion of the Major Proteolytic Site of the Helicobacter pylori Cytotoxin Does Not Influence Toxin Activity but Favors Assembly of the Toxin into Hexameric Structures [O] . Daniela Burroni, Pietro Lupetti, Cristina Pagliaccia, 1998

机译：注意：删除幽门螺杆菌细胞毒素的主要蛋白水解位点不影响毒素活性但有利于将毒素组装成六聚体结构
6. Direct binding of gangliosides to Helicobacter pylori vacuolating cytotoxin (VacA) neutralizes its toxin activity [O] . Wada A., Hasegawa M., Wong P.F., 2010

机译：神经节苷脂与幽门螺杆菌空泡化细胞毒素（VacA）的直接结合可中和其毒素活性

Deletion of the Major Proteolytic Site of theHelicobacter pylori Cytotoxin Does Not Influence Toxin Activity but Favors Assembly of the Toxin into Hexameric Structures

摘要

著录项

相似文献

相关主题

期刊订阅