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Induction of T Helper Type 1 Responses by a Polysaccharide Deacetylase from Cryptococcus neoformans

机译:新型隐球菌多糖脱乙酰基酶诱导T辅助1型应答

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摘要

A 25-kDa cryptococcal deacetylase (d25) was found here to induce cell proliferation, as well as secretion of interleukin 2 and gamma interferon, but not interleukin 4, in spleen cells from d25-immunized or Cryptococcus neoformans-infected mice. The gamma interferon, but not the interleukin 2, response was required for the protective activities of d25 immunization in a murine cryptococcosis model.
机译:在这里,发现一个25kDa的隐球菌脱乙酰酶(d25)可以诱导d25免疫或新隐球菌的脾细胞中的细胞增殖以及白细胞介素2和γ干扰素的分泌,而不是白细胞介素4的分泌。感染的小鼠。在鼠隐球菌病模型中,d25免疫的保护活性需要γ干扰素而不是白介素2反应。

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