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首页> 外文期刊>Infection and immunity >Removal of Wolbachia from Brugia pahangi Is Closely Linked to Worm Death and Fecundity but Does Not Result in Altered Lymphatic Lesion Formation in Mongolian Gerbils (Meriones unguiculatus)
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Removal of Wolbachia from Brugia pahangi Is Closely Linked to Worm Death and Fecundity but Does Not Result in Altered Lymphatic Lesion Formation in Mongolian Gerbils (Meriones unguiculatus)

机译：从Bugia pahangi去除Wolbachia与蠕虫死亡和生殖力密切相关，但不会导致蒙古沙鼠（Meriones unguiculatus）淋巴病变形成改变

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Approximately 30 years ago, researchers reported intracellular bacteria in filarial nematodes. These bacteria are relatives of the arthropod symbiont Wolbachia and occur in many filarial nematodes, including Brugia pahangi and Brugia malayi. Wolbachia bacteria have been implicated in a variety of roles, including filaria development and fecundity and the pathogenesis of lymphatic lesions associated with filarial infections. However, the role of the bacteria in worm biology or filarial disease is still not clear. The present experiments support previous data showing that tetracycline eliminates or reduces Wolbachia bacteria in B. pahangi in vivo. The elimination of Wolbachia was closely linked to a reduction in female fecundity and the viability of both sexes, suggesting that the killing of Wolbachia is detrimental to B. pahangi. The gerbils treated with tetracycline showed reduced levels of interleukin-4 (IL-4) and IL-5 mRNA in renal lymph nodes and spleens compared with the levels in B. pahangi-infected gerbils not treated with tetracycline. However, similar findings were noted in B. pahangi-infected gerbils treated with ivermectin, suggesting that the loss of circulating microfilariae, not the reduction of Wolbachia bacteria, was associated with the altered cytokine profile. Despite the change in T-cell cytokines, there was no difference in the sizes of renal lymph nodes isolated from gerbils in each treatment group. Furthermore, the numbers, sizes, or cellular compositions of granulomas examined in the lymphatics or renal lymph nodes did not differ with treatment. These data suggest that Wolbachia may not play a primary role in the formation of lymphatic lesions in gerbils chronically infected with B. pahangi.
机译：大约30年前，研究人员报道了丝状线虫中的细胞内细菌。这些细菌是节肢动物共生菌“沃尔巴克氏菌”的亲缘种，并存在于许多丝虫线虫中，包括“布鲁日氏菌”和“马来西亚布鲁氏菌”。 Wolbachia 细菌具有多种作用，包括丝虫病的发展和繁殖力以及与丝虫感染相关的淋巴病变的发病机理。但是，细菌在蠕虫生物学或丝虫病中的作用仍不清楚。本实验支持先前的数据，该数据表明四环素消除或减少了 B中的 Wolbachia 细菌。 pahangi 体内。消除 Wolbachia 与女性生殖力的降低和两性的生存能力密切相关，这表明杀死 Wolbachia 对 B是有害的。 pahangi 。与 B中的水平相比，用四环素治疗的沙鼠在肾淋巴结和脾脏中的白细胞介素4（IL-4）和IL-5 mRNA水平降低。未经四环素治疗的彭亨州感染沙鼠。但是，在 B中也发现了类似的发现。用伊维菌素处理感染了帕汉氏菌的沙鼠，这表明循环微丝aria的丧失，而不是沃尔玛氏菌的减少与细胞因子谱的改变有关。尽管T细胞细胞因子发生了变化，但在每个治疗组中，从沙鼠中分离出的肾淋巴结的大小没有差异。此外，在淋巴管或肾淋巴结中检查的肉芽肿的数量，大小或细胞组成与治疗无差异。这些数据表明， Wolbachia 可能在慢性感染 B的沙鼠的淋巴损伤形成中不发挥主要作用。 pahangi 。

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