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首页> 外文期刊>Infection and immunity >Chemokine Expression Patterns Differ within Anatomically Distinct Regions of the Genital Tract during Chlamydia trachomatis Infection
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Chemokine Expression Patterns Differ within Anatomically Distinct Regions of the Genital Tract during Chlamydia trachomatis Infection

机译：沙眼衣原体感染过程中生殖道解剖学不同区域内的趋化因子表达模式不同。

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Untreated infections with Chlamydia trachomatis commonly result in ascending infection to fallopian tubes and subsequent immune-mediated tubal pathology in females. The proposed immune-mediated injury may be associated with the increased recruitment of CD4 cells to the upper genital tract (GT) (oviducts) in comparison to the lower GT (cervix) during infection, as shown in animal models. To understand the mechanisms responsible for this biased recruitment of CD4 cells within the GT, we characterized chemokine expression patterns in the upper and lower GTs in mice during infection with the murine pneumonitis biovar of Chlamydia trachomatis. Enzyme-linked immunosorbent assays of supernatants from GT homogenates revealed that the levels of the Th1-associated chemokines CXCL9 (monokine induced by gamma interferon), CXCL10 (interferon-inducible protein 10), and CCL5 (RANTES) were significantly higher in the upper GT than in the lower GT after infection, while the CCL3 (macrophage inflammatory protein 1α) level was not increased. In contrast, the level of chemokine CCL11 (eotaxin) was significantly elevated in the lower GT later in the course of infection. Increased levels of mRNA confirmed the selective differences in chemokine expression within the upper and lower GTs. The increased levels of Th1-inducible chemokines in the upper GT were not due to differences in the magnitude of infection or progesterone pretreatment. These data demonstrate that the upper and lower regions of the GT respond differently to Chlamydia infection.
机译：未经治疗的衣原体 沙眼感染通常会导致女性输卵管感染上升，并随后发生免疫介导的输卵管病理。拟议的免疫介导的损伤可能与CD4细胞在感染过程中与下层GT（子宫颈）感染相比增加了向上生殖道（GT）（输卵管）的募集有关，如动物模型所示。为了了解导致GT中CD4细胞偏向募集的机制，我们对小鼠肺炎衣原体 气管炎的鼠肺炎病毒感染过程中小鼠上部和下部GT的趋化因子表达模式进行了表征。 / em>。 GT匀浆上清液的酶联免疫吸附测定表明，Th1上趋化因子CXCL9（γ干扰素诱导的单核细胞因子），CXCL10（干扰素诱导性蛋白10）和CCL5（RANTES）的水平在GT上部明显更高与感染后较低的GT相比，CCL3（巨噬细胞炎性蛋白1α）水平没有增加。相反，在感染过程后期，较低的GT中趋化因子CCL11（eotaxin）的水平显着升高。 mRNA水平的升高证实了上，下GT内趋化因子表达的选择性差异。较高的GT中Th1诱导型趋化因子水平升高并非由于感染程度或孕激素预处理的差异所致。这些数据表明，GT的上部和下部对衣原体感染的反应不同。

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