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Skin Facilitates Candida albicans Mating

机译：皮肤促进白色念珠菌交配

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Mating between natural >a/a and α/α strains of Candida albicans requires that cells first switch from the white to opaque phase phenotype. However, because cells expressing the opaque phase phenotype are induced to switch back to the white phase phenotype at physiological temperature (37°C) and because opaque phase cells are highly efficient at colonizing skin, we tested whether skin, which is several degrees lower than physiological temperature, is conducive to mating. Using a model in which a mixture of >a/a and α/α cells are incubated for 24 h under a cotton patch on the hairless skin of newborn mice and using scanning electron microscopy to visualize cells on skin, it was demonstrated that skin facilitates mating. In some regions of the skin, 40% of all cells had fused. All of the stages of mating observed in vitro were observed in vivo. However, some unique morphological characteristics of mating on skin were observed and are attributable to parent cell immobilization on the skin. In control experiments on glass, plastic, and silicone elastomer surfaces at 32°C, cells either failed to fuse or did so at an extremely low frequency, suggesting that unique features of the skin surface other than reduced temperature also facilitate fusion.
机译：在白色念珠菌的自然> a / a 和α/α菌株之间进行交配需要细胞首先从白色相转变为不透明相表型。但是，由于在生理温度（37°C）下，表达不透明相表型的细胞被诱导转换回白相表型，并且由于不透明相细胞在移殖皮肤方面非常有效，因此我们测试了皮肤是否比皮肤低几度。生理温度高，有利于交配。使用将> a / a 和α/α细胞的混合物在新生小鼠无毛皮肤上的棉布下孵育24小时的模型，并使用扫描电子显微镜观察皮肤上的细胞，事实证明，皮肤有助于交配。在皮肤的某些区域，所有细胞中有40％融合了。体内观察到了体外观察到的所有交配阶段。但是，观察到了交配在皮肤上的一些独特的形态学特征，这归因于亲代细胞在皮肤上的固定。在玻璃，塑料和有机硅弹性体表面在32°C下进行的对照实验中，细胞要么无法融合，要么以极低的频率融合，这表明除降低温度外，皮肤表面的独特特征也促进融合。

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