Mycobacterium avium subsp. paratuberculosis Infection Causes Suppression of RANTES, Monocyte Chemoattractant Protein 1, and Tumor Necrosis Factor Alpha Expression in Peripheral Blood of Experimentally Infected Cattle

Joram J. Buza; Yasuyuki Mori; Abusaleh M. Bari; Hirokazu Hikono Aodon-geril; Sachiyo Hirayama; Yujing Shu

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Mycobacterium avium subsp. paratuberculosis Infection Causes Suppression of RANTES, Monocyte Chemoattractant Protein 1, and Tumor Necrosis Factor Alpha Expression in Peripheral Blood of Experimentally Infected Cattle

机译：鸟分枝杆菌亚种副结核病感染导致实验感染牛外周血中RANTES，单核细胞趋化蛋白1和肿瘤坏死因子α表达的抑制

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Blood from cattle with subclinical Mycobacterium avium subsp. paratuberculosis infection was stimulated with M. avium subsp. paratuberculosis antigens, and expression of interleukin-1β (IL-1β), tumor necrosis factor alpha (TNF-α), RANTES, monocyte chemoattractant protein 1 (MCP-1), and IL-8 was measured. Expression of TNF-α, RANTES, and MCP-1 was lower in infected than in uninfected cattle. The reduced response may weaken protective immunity and perpetuate infection.

机译：来自亚临床鸟分枝杆菌亚种的牛血。用 M刺激肺结核感染。 avium 子空间检测肺结核抗原，白细胞介素1β（IL-1β），肿瘤坏死因子α（TNF-α），RANTES，单核细胞趋化蛋白1（MCP-1）和IL-8的表达。受感染的牛的TNF-α，RANTES和MCP-1的表达低于未感染的牛。反应降低可能会削弱保护性免疫力并永久感染。 展开▼

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《Infection and immunity》 |2003年第12期|共5页

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Joram J. Buza; Yasuyuki Mori; Abusaleh M. Bari; Hirokazu Hikono Aodon-geril; Sachiyo Hirayama; Yujing Shu;
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中图分类医学免疫学;

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1. Neutralization of Interleukin-10 Significantly Enhances Gamma Interferon Expression in Peripheral Blood by Stimulation with Johnin Purified Protein Derivative and by Infection with Mycobacterium avium subsp. paratuberculosis in Experimentally Infected Cattle with Paratuberculosis [J] . Joram J. Buza, Hirokazu Hikono, Yasuyuki Mori, Infection and immunity . 2004,第4期

机译：通过用Johnin纯化的蛋白衍生物刺激和通过鸟分枝杆菌亚种感染，白细胞介素10的中和作用显着增强了外周血中的γ干扰素表达。实验性感染副结核病牛的副结核病

2. Enhanced Expression of Interleukin-1α and Tumor Necrosis Factor Receptor-Associated Protein 1 in Ileal Tissues of Cattle Infected with Mycobacterium avium subsp. paratuberculosis [J] . Abraham D. Aho, Amanda M. McNulty, Paul M. Coussens Infection and immunity . 2003,第11期

机译：白介素1α和肿瘤坏死因子受体相关蛋白1在禽分枝杆菌亚种感染的牛回肠组织中的增强表达。副结核病

3. Corticotropin-releasing hormone and urocortin expression in peripheral blood cells from experimentally infected cattle with Mycobacterium avium subsp. paratuberculosis. [J] . Wang H, Aodon geril, Shu Y, Microbes and infection . 2007,第9期

机译：鸟分枝杆菌亚种实验感染牛外周血中促肾上腺皮质激素释放激素和尿皮质素的表达。副结核病。

4. PPE proteins of Mycobacterium avium subspecies paratuberculosis induce interferon-gamma production by peripheral blood mononuclear cells from infected cattle [C] . Nagata R, Muneta Y, Mori Y International Colloquium on Paratuberculosis . 2007

机译：分枝杆菌的PPE蛋白亚种亚种分枝杆菌诱导受感染牛外周血单核细胞的干扰素 - γ产生

5. The regulation of the monocyte chemoattractant protein-1 by tumor necrosis factor-alpha requires activation of transcription factors, chromatin modification, and long distance protein-protein communication. [D] . Boekhoudt, Gunther Heinrich. 2003

机译：肿瘤坏死因子-α对单核细胞趋化蛋白-1的调节需要激活转录因子，染色质修饰和长距离蛋白-蛋白通讯。

6. Mycobacterium avium subsp. paratuberculosis Infection Causes Suppression of RANTES Monocyte Chemoattractant Protein 1 and Tumor Necrosis Factor Alpha Expression in Peripheral Blood of Experimentally Infected Cattle [O] . Joram J. Buza, Yasuyuki Mori, Abusaleh M. Bari, 2003

机译：鸟分枝杆菌亚种副结核病感染导致实验感染牛外周血中RANTES单核细胞趋化蛋白1和肿瘤坏死因子α表达的抑制

7. Mycobacterium avium subsp. paratuberculosis Infection Causes Suppression of RANTES, Monocyte Chemoattractant Protein 1, and Tumor Necrosis Factor Alpha Expression in Peripheral Blood of Experimentally Infected Cattle [O] . Buza, Joram J., Mori, Yasuyuki, Bari, Abusaleh M., 2003

机译：鸟分枝杆菌亚种副结核病感染导致实验感染牛外周血中RANTES，单核细胞趋化蛋白1和肿瘤坏死因子α表达的抑制

1. 基质金属蛋白酶-1及其组织抑制因子-1、肿瘤坏死因子-α在溃疡性结肠炎患者外周血中的表达及其意义 [J] . 杨熹 . 实用临床医药杂志 . 2012,第017期

2. 血清单核细胞趋化蛋白1（MCP-1）在肺癌及肺结核患者外周血中的表达及相关性研究 [J] . 张琳琳 ,郭其森 . 医学信息 . 2014,第013期

3. 鸭乙型肝炎病毒实验感染樱桃谷鸭后在肝脏和外周血中的动态 [J] . 邓学龙 ,方宏勋 . 广州中医药大学学报 . 1997,第001期

4. MIP-1α、RANTES在肝癌患者外周血中的表达及临床意义 [J] . 石薇 ,陈永顺 . 医学分子生物学杂志 . 2018,第004期

5. RANTES在银屑病患者外周血中的表达及其临床意义 [J] . 唐玲 ,于益芝 ,唐跃琼 . 中国麻风皮肤病杂志 . 2003,第001期

6. 牛外周血中性粒细胞干扰素诱导基因在牛结核病感染中的转录水平变化 [C] . 王进 ,周向梅 ,徐镔蕊 . 2013年中国畜牧兽医学会兽医病理学分会暨中国病理生理学会动物病理生理学专业委员会学术研讨会 . 2013

7. 外周血中抗原阴性的HBV感染者肝组织病理改变及组织中HBVDNA表达状态与外周血中HBVM表达模式的相关性研究 [A] . 彭思璐 . 2016

1. Recombinant mycobacterium avium subsp. paratuberculosis proteins induce immunity and protect against infection [P] . 外国专利： US9175049B2 . 2015-11-03

机译：重组鸟分枝杆菌亚种。肺结核副蛋白诱导免疫力并预防感染

2. RECOMBINANT MYCOBACTERIUM AVIUM SUBSP. PARATUBERCULOSIS PROTEINS INDUCE IMMUNITY AND PROTECT AGAINST INFECTION [P] . 外国专利： WO2014066162A1 . 2014-05-01

机译：重组分枝杆菌AV虫亚种。肺炎链球菌蛋白诱导免疫力和抗感染性。

3. Recombinant Mycobacterium Avium Subsp. Paratuberculosis Proteins Induce Immunity and Protect Against Infection [P] . 外国专利： US2014112949A1 . 2014-04-24

机译：重组分枝杆菌Avium亚种。副结核蛋白可诱导免疫力并预防感染

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Mycobacterium avium subsp. paratuberculosis Infection Causes Suppression of RANTES, Monocyte Chemoattractant Protein 1, and Tumor Necrosis Factor Alpha Expression in Peripheral Blood of Experimentally Infected Cattle

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