Protection against Anthrax Toxemia by Hexa-d-Arginine In Vitro and In Vivo

Miroslav S. Sarac; Juan R. Peinado; Stephen H. Leppla; Iris Lindberg

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Protection against Anthrax Toxemia by Hexa-d-Arginine In Vitro and In Vivo

机译：Hexa-d-精氨酸在体内和体内对炭疽毒素的保护作用

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The anthrax toxin protective antigen precursor is activated by proteolytic cleavage by furin or a furin-like protease. We present here data demonstrating that the small stable furin inhibitor hexa-d-arginine amide delays anthrax toxin-induced toxemia both in cells and in live animals, suggesting that furin inhibition may represent a reasonable avenue for therapeutic intervention in anthrax.

机译：炭疽毒素保护性抗原前体通过弗林蛋白酶或弗林蛋白酶样蛋白酶的蛋白水解切割而被激活。我们在这里提供的数据表明，稳定的小型弗林蛋白酶抑制剂六-d-精氨酸酰胺可延缓炭疽毒素在细胞和活体动物中引起的毒血症，这表明弗林蛋白酶抑制作用可能代表了对炭疽进行治疗性干预的合理途径。

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《Infection and immunity》 |2004年第1期|共4页
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Miroslav S. Sarac; Juan R. Peinado; Stephen H. Leppla; Iris Lindberg;
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中图分类医学免疫学;
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6. Protection against Anthrax Toxemia by Hexa-d-Arginine In Vitro and In Vivo [O] . Miroslav S. Sarac, Juan R. Peinado, Stephen H. Leppla, 2004

机译：Hexa-d-精氨酸在体内和体内对炭疽毒素的保护作用
7. Protection against Anthrax Toxemia by Hexa-d-Arginine In Vitro and In Vivo [O] . Sarac, Miroslav S., Peinado, Juan R., Leppla, Stephen H., 2004

机译：Hexa-d-精氨酸在体内和体内对炭疽毒素的保护作用

Protection against Anthrax Toxemia by Hexa-d-Arginine In Vitro and In Vivo

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