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首页> 外文期刊>Infection and immunity >Inhibition of Endothelial Interleukin-8 Production and Neutrophil Transmigration by Staphylococcus aureus Beta-Hemolysin
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Inhibition of Endothelial Interleukin-8 Production and Neutrophil Transmigration by Staphylococcus aureus Beta-Hemolysin

机译：金黄色葡萄球菌β-溶血素抑制内皮白细胞介素8的产生和中性粒细胞的迁移。

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摘要

Neutrophils play a crucial role in the host response to infection with Staphylococcus aureus, which is a major human pathogen capable of causing life-threatening disease. Interleukin-8 (IL-8) is a potent chemoattractant and activator of neutrophils. We previously reported that S. aureus secretes a factor that suppresses IL-8 production by human endothelial cells. Here we isolated an inhibitor of IL-8 production from the supernatant and identified it as staphylococcal beta-hemolysin. Beta-hemolysin reduced IL-8 production without cytotoxicity to endothelial cells. Pretreatment with beta-hemolysin decreased the expression of both IL-8 mRNA and protein induced by tumor necrosis factor alpha (TNF-α). Migration of neutrophils across TNF-α-activated endothelium was also inhibited by beta-hemolysin. In contrast, beta-hemolysin had no effect on intercellular adhesive molecule 1 expression in activated endothelial cells. These results showed that beta-hemolysin produced by S. aureus interferes with inflammatory signaling in endothelial cells and may help S. aureus evade the host immune response.
机译：中性粒细胞在宿主对金黄色葡萄球菌感染的反应中起着至关重要的作用，金黄色葡萄球菌是一种能够引起生命危险的主要人类病原体。白细胞介素8（IL-8）是一种有效的趋化性和嗜中性粒细胞活化剂。我们之前曾报道过 S。金黄色葡萄球菌分泌一种抑制人内皮细胞产生IL-8的因子。在这里，我们从上清液中分离出一种IL-8生成抑制剂，并将其鉴定为葡萄球菌β-溶血素。 β-溶血素减少了IL-8的产生，而对内皮细胞没有细胞毒性。用β-溶血素进行预处理可降低肿瘤坏死因子α（TNF-α）诱导的IL-8 mRNA和蛋白的表达。 β-溶血素也抑制嗜中性粒细胞跨TNF-α活化的内皮的迁移。相反，β-溶血素对活化的内皮细胞中的细胞间粘附分子1表达没有影响。这些结果表明，由 S产生的β-溶血素。金黄色干扰内皮细胞的炎症信号传导，可能有助于 S。金黄色葡萄球菌能逃避宿主的免疫反应。

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