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首页> 外文期刊>Infection and immunity >Subcellular Localization of the Staphylococcus aureus Heme Iron Transport Components IsdA and IsdB
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Subcellular Localization of the Staphylococcus aureus Heme Iron Transport Components IsdA and IsdB

机译：金黄色葡萄球菌血红素铁转运成分IsdA和IsdB的亚细胞定位

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Staphylococcus aureus is a human pathogen that represents a tremendous threat to global public health. An important aspect of S. aureus pathogenicity is the ability to acquire iron from its host during infection. In vertebrates, iron is sequestered predominantly within heme, the majority of which is bound by hemoglobin. To acquire iron, S. aureus binds hemoglobin, removes heme, and transports it into the cytoplasm, where heme is degraded. This process is carried out by the iron-regulated surface determinant system (Isd); however, the mechanism by which hemoglobin recognition occurs is not completely understood. Here we report that the surface receptor components of the Isd system, IsdA and IsdB, physically interact with each other and are anchored to a discrete location within the cell wall. This organized localization pattern is dependent upon the iron status of the bacterium. Furthermore, we have found that hemoglobin colocalizes with IsdB at discrete sites within the cell wall. Virulence studies revealed that IsdB is required for the efficient colonization of the heart and that IsdB is differentially expressed within infected organs, suggesting that S. aureus experiences various degrees of iron starvation depending on the site of infection. These findings significantly expand our understanding of hemoglobin iron acquisition and demonstrate an orchestrated pattern of regulation and localization for the S. aureus heme iron acquisition system.
机译：金黄色葡萄球菌是一种人类病原体，对全球公共健康构成巨大威胁。 S的重要方面。金黄色葡萄球菌的致病性是在感染过程中从宿主体内获取铁的能力。在脊椎动物中，铁主要被螯合在血红素中，其中大部分被血红蛋白结合。要获取铁， S。金黄色葡萄球菌结合血红蛋白，去除血红素，然后将其转运到细胞质中，在那里血红素被降解。此过程由铁调节的表面行列式系统（Isd）进行;但是，尚不完全了解发生血红蛋白识别的机制。在这里，我们报告Isd系统的表面受体成分IsdA和IsdB彼此物理相互作用，并锚定到细胞壁内的离散位置。这种有组织的定位模式取决于细菌的铁状态。此外，我们发现血红蛋白在细胞壁的离散部位与IsdB共定位。毒力研究表明，IsdB是心脏有效定居所必需的，并且IsdB在受感染的器官中差异表达，这表明 S。根据感染部位，金黄色葡萄球菌会遭受不同程度的铁饥饿。这些发现极大地扩展了我们对血红蛋白铁获取的理解，并证明了 S的协调性调节和定位模式。金黄色素血红素铁采集系统。

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