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首页> 外文期刊>Infection and immunity >Peyer's Patch-Deficient Mice Demonstrate That Mycobacterium avium subsp. paratuberculosis Translocates across the Mucosal Barrier via both M Cells and Enterocytes but Has Inefficient Dissemination
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Peyer's Patch-Deficient Mice Demonstrate That Mycobacterium avium subsp. paratuberculosis Translocates across the Mucosal Barrier via both M Cells and Enterocytes but Has Inefficient Dissemination

机译：Peyer的斑块缺陷小鼠证明鸟分枝杆菌亚种。副结核病通过M细胞和肠上皮细胞跨粘膜屏障转运，但传播效率低下

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Mycobacterium avium subsp. paratuberculosis, the agent of Johne's disease, infects ruminant hosts by translocation through the intestinal mucosa. A number of studies have suggested that M. avium subsp. paratuberculosis interacts with M cells in the Peyer's patches of the small intestine. The invasion of the intestinal mucosa by M. avium subsp. paratuberculosis and Mycobacterium avium subsp. hominissuis, a pathogen known to interact with intestinal cells, was compared. M. avium subsp. paratuberculosis was capable of invading the mucosa, but it was significantly less efficient at dissemination than M. avium subsp. hominissuis. B-cell knockout (KO) mice, which lack Peyer's patches, were used to demonstrate that M. avium subsp. paratuberculosis enters the intestinal mucosa through enterocytes in the absence of M cells. In addition, the results indicated that M. avium subsp. paratuberculosis had equal abilities to cross the mucosa in both Peyer's patch and non-Peyer's patch segments of normal mice. M. avium subsp. paratuberculosis was also shown to interact with epithelial cells by an α5β1 integrin-independent pathway. Upon translocation, dendritic cells ingest M. avium subsp. paratuberculosis, but this process does not lead to efficient dissemination of the infection. In summary, M. avium subsp. paratuberculosis interacts with the intestinal mucosa by crossing both Peyer's patches and non-Peyer's patch areas but does not translocate or disseminate efficiently.
机译：鸟分枝杆菌子亚种。约翰德氏病的病原体肺结核通过转位穿过肠粘膜感染反刍动物宿主。许多研究表明， M。 avium 子空间肺结核与小肠Peyer斑中的M细胞相互作用。肠粘膜被 M侵袭。 avium 子空间副结核和鸟分枝杆菌亚种。比较了已知与肠道细胞相互作用的病原体 hominissuis 。 M。 avium 子空间肺结核能够侵袭粘膜，但传播效率远低于 M。 avium 子空间 hominissuis 。缺乏Peyer斑块的B细胞敲除（KO）小鼠用于证明 M。 avium 子空间在没有M细胞的情况下，肺结核通过肠上皮细胞进入肠粘膜。另外，结果表明 M。 avium 子空间在正常小鼠的Peyer's斑块和非Peyer's斑块部分，肺结核具有相同的穿透粘膜的能力。 M。 avium 子空间还显示副结核通过不依赖α 5 β 1 整合素的途径与上皮细胞相互作用。易位后，树突状细胞摄入M。 avium 子空间肺结核，但是此过程不会导致感染的有效传播。总之， M。 avium 子空间肺结核通过穿过Peyer的斑块和非Peyer的斑块区域与肠道粘膜相互作用，但不能有效地移位或传播。

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