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Activation of Human and Chicken Toll-Like Receptors by Campylobacter spp.

机译：弯曲杆菌属物种激活人和鸡类似收费的受体。

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Campylobacter infection in humans is accompanied by severe inflammation of the intestinal mucosa, in contrast to colonization of chicken. The basis for the differential host response is unknown. Toll-like receptors (TLRs) sense and respond to microbes in the body and participate in the induction of an inflammatory response. Thus far, the interaction of Campylobacter with chicken TLRs has not been studied. Here, we investigated the potential of four Campylobacter strains to activate human TLR1/2/6, TLR4, TLR5, and TLR9 and chicken TLR2t2/16, TLR4, TLR5, and TLR21. Live bacteria showed no or very limited potential to activate TLR2, TLR4, and TLR5 of both the human and chicken species, with minor but significant differences between Campylobacter strains. In contrast, lysed bacteria induced strong NF-κB activation through human TLR1/2/6 and TLR4 and chicken TLR2t2/16 and TLR4 but not via TLR5 of either species. Interestingly, C. jejuni induced TLR4-mediated beta interferon in human but not chicken cells. Furthermore, isolated chromosomal Campylobacter DNA was unable to activate human TLR9 in our system, whereas chicken TLR21 was activated by DNA from all of the campylobacters tested. Our data are the first comparison of TLR-induced immune responses in humans and chickens. The results suggest that differences in bacterial cell wall integrity and in TLR responses to Campylobacter LOS and/or DNA may contribute to the distinct clinical manifestation between the species.
机译：与鸡的定殖相反，人的弯曲杆菌感染伴随着肠道粘膜的严重炎症。差分主机响应的基础未知。 Toll样受体（TLR）感应并响应体内的微生物，并参与诱导炎症反应。迄今为止，尚未研究弯曲杆菌与鸡TLR的相互作用。在这里，我们调查了四个弯曲杆菌菌株激活人TLR1 / 2/6，TLR4，TLR5和TLR9以及鸡TLR2t2 / 16，TLR4，TLR5和TLR21的潜力。活细菌显示出没有或非常有限的激活人类和鸡种的TLR2，TLR4和TLR5的潜力，弯曲杆菌菌株之间存在微小但显着的差异。相比之下，裂解细菌通过人TLR1 / 2/6和TLR4，鸡TLR2t2 / 16和TLR4诱导了强烈的NF-κB活化，但没有通过任何一种的TLR5诱导。有趣的是，空肠弯曲杆菌在人而非鸡​​细胞中诱导了TLR4介导的β干扰素。此外，在我们的系统中，分离的染色体弯曲杆菌DNA无法激活人TLR9，而所有测试弯曲杆菌中的DNA都激活了鸡TLR21。我们的数据是TLR诱导的人和鸡免疫应答的首次比较。结果表明细菌细胞壁完整性和对弯曲杆菌LOS和/或DNA的TLR反应的差异可能有助于物种之间的不同临床表现。

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