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首页> 外文期刊>Infection and immunity >CD23b Isoform Expression in Human Schistosomiasis Identifies a Novel Subset of Activated B Cells
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CD23b Isoform Expression in Human Schistosomiasis Identifies a Novel Subset of Activated B Cells

机译：在人类血吸虫病中的CD23b亚型表达确定了激活的B细胞的一个新的子集。

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Resistance to schistosomiasis is associated with increased levels of serum parasite-specific IgE. IgE exerts its functions through its cellular receptors, FcεRI and FcεRII/CD23; however, its functional significance in humans requires further characterization. We previously reported that increased levels of CD23+ B cells correlate with resistance to schistosomiasis in hyperexposed populations and sought to define their potential function and relationship with IgE. We found that CD23+ B cells are a heterogeneous cell population with functional and phenotypic differences. Circulating CD23+ B cells are uniquely activated in schistosomiasis and express the CD23b isoform and CXCR5, the homing receptor for lymphoid follicles. High CXCR5 expression by CD23+ B cells was associated with the capacity to home to the cognate ligand CXCL13. CD23-bound IgE cross-linking increased surface expression of CXCR5, suggesting that CD23+ B cells home directly into the lymphoid follicles upon antigen capture. As human schistosomiasis is an intravascular parasitic infection associated with a high antigenic burden in the blood, circulating CD23+ B cells may play a role in the capture and shuttling of antigens directly to splenic follicles, highlighting a new role for circulating B cells. This function likely plays an important role in the development of protective immunity to infection with schistosomes.
机译：对血吸虫病的耐药性与血清寄生虫特异性IgE水平升高有关。 IgE通过其细胞受体FcεRI和FcεRII/ CD23发挥其功能;但是，其在人类中的功能重要性需要进一步表征。我们以前曾报道过，CD23 + B细胞水平升高与过度暴露人群对血吸虫病的抗性相关，并试图确定其潜在功能和与IgE的关系。我们发现CD23 + B细胞是具有功能和表型差异的异种细胞群体。循环血CD23 + B细胞在血吸虫病中被唯一激活，并表达CD23b亚型和CXCR5（淋巴滤泡的归巢受体）。 CD23 + B细胞的高CXCR5表达与同源配体CXCL13的归巢能力有关。 CD23结合的IgE交联增加了CXCR5的表面表达，表明CD23 + B细胞在捕获抗原后直接进入淋巴滤泡。由于人类血吸虫病是一种血管内寄生虫感染，伴有血液中的高抗原负担，循环中的CD23 + B细胞可能在抗原直接捕获和穿梭于脾滤泡中发挥作用，这突出了新的作用用于循环B细胞。该功能可能在发展对血吸虫感染的保护性免疫中起重要作用。

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