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首页> 外文期刊>Infection and immunity >Adaptive Immunity against Listeria monocytogenes in the Absence of Type I Tumor Necrosis Factor Receptor p55
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Adaptive Immunity against Listeria monocytogenes in the Absence of Type I Tumor Necrosis Factor Receptor p55

机译：在没有I型肿瘤坏死因子受体p55的情况下针对单核细胞增生性李斯特菌的适应性免疫

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摘要

Tumor necrosis factor (TNF) and the type I TNF receptor (TNFRI), p55, are critical for resistance against primary infections with the intracellular bacterial pathogen Listeria monocytogenes. Importantly, however, susceptibility to primary listeriosis in cytokine-deficient mice does not preclude the development or expression of effective adaptive immunity against virulent L. monocytogenes. We used TNFRI?/? mice to study adaptive antilisterial immunity in the absence of interactions between TNF and TNFRI. Our experiments indicate that TNFRI?/? mice survive and clear high-dose challenges with an attenuated strain of L. monocytogenesthat is incapable of cell-to-cell spread. Furthermore, TNFRI?/? mice immunized with attenuatedL. monocytogenes go on to develop potent adaptive immunity to subsequent high-dose challenges with virulent L. monocytogenes. Interestingly, CD8+ T-cell depletion in vivo inhibits immunity to L. monocytogenes in the spleen but not in the liver of TNFRI?/? mice. The adaptive immune response in these animals is characterized by activation of listeriolysin O-specific CD8+ T cells, which are capable of transferring antilisterial immunity to naive wild-type C57BL/6 host mice. These experiments demonstrate the development and expression of potent CD8+ T-cell-mediated antilisterial immunity in the absence of TNFRI.
机译：肿瘤坏死因子（TNF）和I型TNF受体（TNFRI）p55对抵抗细胞内细菌病原体李斯特菌的原发感染至关重要。然而，重要的是，在细胞因子缺乏的小鼠中对原发性李斯特菌病的易感性并不排除针对毒性 L的有效适应性免疫的发展或表达。单核细胞增生。我们使用TNFRI ？/？小鼠研究在TNF和TNFRI之间不存在相互作用的情况下的适应性抗李斯特菌免疫。我们的实验表明，TNFRI ？/？小鼠存活并清除了 L减毒株，克服了大剂量攻击。单核细胞增生无法在细胞间扩散。此外，用减毒的 L免疫的TNFRI α/β小鼠。单核细胞增生病继续发展出强大的适应性免疫力，可抵抗强毒的 L随后的高剂量攻击。单核细胞增生。有趣的是，体内CD8 + T细胞耗竭抑制了对 L的免疫。 TNFRI ？/？小鼠的脾脏中单核细胞增生而不是肝脏中。这些动物的适应性免疫反应的特征是激活了李斯特菌溶血素O特异性CD8 + T细胞，该细胞能够将抗李斯特菌免疫力转移至幼稚的野生型C57BL / 6宿主小鼠。这些实验证明了在没有TNFRI的情况下有效的CD8 + T细胞介导的抗李斯特菌免疫性的发展和表达。

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