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首页> 外文期刊>Infection and immunity >Antigen-Specific Responses to Diphtheria-Tetanus-Acellular Pertussis Vaccine in Human Infants Are Initially Th2 Polarized
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Antigen-Specific Responses to Diphtheria-Tetanus-Acellular Pertussis Vaccine in Human Infants Are Initially Th2 Polarized

机译：对婴儿中白喉-破伤风-无细胞百日咳疫苗的抗原特异性反应最初是Th2极化的。

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Immune responses to exogenous antigens in infant experimental animals display various degrees of Th2 polarization. Preliminary evidence from small human studies suggest a similar age-dependent response pattern to vaccines, but detailed investigations on vaccine immunity during infancy have not yet been undertaken. We report below the results of a comprehensive prospective study on responses to the tetanus component of the diphtheria, tetanus, acellular pertussis (DTaP) vaccine in a cohort of 55 healthy children, employing peripheral blood mononuclear cells (PBMC) collected at the 2-, 4-, and 6-month vaccinations and at 12 months. Antigen-specific production of interleukin-4 (IL-4), IL-5, IL-6, IL-9, IL-10, IL-13, and gamma interferon (IFN-γ) was determined at each sample point, in parallel with polyclonal (phytohemagglutinin PHA-induced) cytokine responses. Our results indicate early and persistent Th2 responses to the vaccine, in contrast to a more delayed and transient pattern of IFN-γ production. This initial disparity between the Th1 and Th2 components of the vaccine response was mirrored by patterns of polyclonally induced cytokine production, suggesting that the delayed maturation of the Th1 component of the vaccine response during infancy is secondary to developmental processes occurring within the overall Th cell system.
机译：婴儿实验动物对外源抗原的免疫反应显示出不同程度的Th2极化。小型人体研究的初步证据表明，疫苗的年龄依赖性反应模式相似，但尚未进行婴儿期疫苗免疫的详细研究。我们在以下55位健康儿童的队列中报告了对白喉，破伤风，无细胞百日咳（DTaP）疫苗的破伤风成分的反应的全面前瞻性研究结果，采用了在2时收集的外周血单核细胞（PBMC）， 4、6个月的疫苗接种以及12个月的疫苗接种。在每个样品点测定白细胞介素4（IL-4），IL-5，IL-6，IL-9，IL-10，IL-13和γ干扰素（IFN-γ）的抗原特异性产生。与多克隆（植物血凝素PHA诱导）细胞因子反应平行。我们的结果表明对疫苗的早期和持久性Th2反应，与IFN-γ产生的更延迟和瞬时模式相反。疫苗反应中Th1和Th2成分之间的初始差异通过多克隆诱导的细胞因子产生的模式反映出来，表明婴儿期疫苗反应中Th1成分的延迟成熟是整个Th细胞系统内发生的发育过程的继发因素。

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