In Vivo Administration of Mycobacterial Cord Factor (Trehalose 6,6′-Dimycolate) Can Induce Lung and Liver Granulomas and Thymic Atrophy in Rabbits

Naoko Hamasaki; Ko-Ichi Isowa; Kohachi Kamada; Yoshitake Terano; Takayuki Matsumoto; Tetsuo Arakawa; Kazuo Kobayashi; Ikuya Yano

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In Vivo Administration of Mycobacterial Cord Factor (Trehalose 6,6′-Dimycolate) Can Induce Lung and Liver Granulomas and Thymic Atrophy in Rabbits

机译：体内施用分枝杆菌脐带因子（海藻糖6,6'-二霉菌酸酯）可诱导兔肺和肝肉芽肿和胸腺萎缩

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Trehalose 6,6′-dimycolate (TDM) is a cell surface molecule ofMycobacterium tuberculosis. TDM induced a loss of body weight and prominent granulomas in the liver and lungs by the intravenous injection of TDM into rabbits. TDM also induced atrophy of the thymus and spleen due to apoptosis. By contrast, sulfolipid (2,3,6,6′-tetraacyl trehalose 2′-sulfate) induced neither toxicity, nor granuloma formation, nor atrophy of the thymus and spleen. In rabbits the histopathological changes were more dramatic than in mice. The rabbit model may be more sensitive and may provide more information on the beneficial or pathological effects of TDM.

机译：海藻糖6,6'-二霉菌酸酯（TDM）是结核分枝杆菌的细胞表面分子。通过将TDM静脉内注射到兔体内，TDM导致体重减轻和肝脏和肺部明显的肉芽肿。由于细胞凋亡，TDM还引起胸腺和脾萎缩。相反，硫脂（2,3,6,6'-四酰基海藻糖2'-硫酸盐）既不引起毒性，也不引起肉芽肿形成，也不引起胸腺和脾萎缩。在兔子中，组织病理学变化比在小鼠中更为显着。兔子模型可能更敏感，可以提供有关TDM有益或病理作用的更多信息。

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《Infection and immunity》 |2000年第6期|共6页
作者
Naoko Hamasaki; Ko-Ichi Isowa; Kohachi Kamada; Yoshitake Terano; Takayuki Matsumoto; Tetsuo Arakawa; Kazuo Kobayashi; Ikuya Yano;
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中图分类医学免疫学;
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1. Cytokine message and protein expression during lung granuloma formation and resolution induced by the mycobacterial cord factor trehalose-6,6'-dimycolate. [J] . Perez RL, Roman J, Roser S, Journal of interferon and cytokine research: The official journal of the International Society for Interferon and Cytokine Research . 2000,第9期

机译：肺肉芽肿形成过程中的细胞因子信息和蛋白质表达，以及由分枝杆菌脐带因子海藻糖-6,6'-二霉酚酸酯诱导的消退。
2. In vivo induction of apoptosis in the thymus by administration of mycobacterial cord factor (trehalose 6,6'-dimycolate). [J] . Y Ozeki, K Kaneda, N Fujiwara, Infection and immunity . 1997,第5期

机译：通过施用分枝杆菌脐带因子（海藻糖6,6'-二霉菌酸酯）在体内诱导胸腺细胞凋亡。
3. In vivo induction of apoptosis in the thymus by administration of mycobacterial cord factor (trehalose 6,6'-dimycolate). [J] . Y Ozeki, K Kaneda, N Fujiwara, Infection and immunity . 1997,第5期

机译：通过施用分枝杆菌脐带因子（海藻糖6,6'-二霉菌酸酯）在体内诱导胸腺细胞凋亡。
4. Injectable sonication-induced silk hydrogel for dual factors delivery to elevate the maxillary sinus floor in rabbit [C] . Wenjie Zhang, Xiuli Wang, David L. Kaplan World biomaterials congress . 2012

机译：注射声波诱导丝水凝胶用于双因子递送以提高兔上颌窦底
5. Hypersensitive granulomatous response to mycobacterial glycolipid trehalose 6,6'-dimycolate. [D] . Guidry, Tera Vale. 2006

机译：对分枝杆菌糖脂海藻糖6,6'-二霉菌酸酯的过敏性肉芽肿反应。
6. Note: In Vivo Administration of Mycobacterial Cord Factor (Trehalose 66′-Dimycolate) Can Induce Lung and Liver Granulomas and Thymic Atrophy in Rabbits [O] . Naoko Hamasaki, Ko-Ichi Isowa, Kohachi Kamada, 2000

机译：注意：分枝杆菌脐带因子（海藻糖66-二霉菌酸酯）的体内给药可诱发兔的肺和肝肉芽肿和胸腺萎缩
7. In vivo induction of apoptosis in the thymus by administration of mycobacterial cord factor (trehalose 6,6'-dimycolate) [O] . Y Ozeki, K Kaneda, N Fujiwara, 1997

机译：通过施用分枝杆菌因子（海藻糖6,6'-二氯化物）体内诱导胸腺凋亡
8. IgE-Induced Release of a Platelet-Activating Factor from Rabbit Lung. [R] . Kravis, T. C., Henson, P. M. 1975

机译：IgE诱导的兔肺血小板活化因子的释放。

In Vivo Administration of Mycobacterial Cord Factor (Trehalose 6,6′-Dimycolate) Can Induce Lung and Liver Granulomas and Thymic Atrophy in Rabbits

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