Induction of T Helper Type 1 and 2 Responses to 19-Kilodalton Merozoite Surface Protein 1 in Vaccinated Healthy Volunteers and Adults Naturally Exposed to Malaria

Edwin A. M. Lee; Dupeh R. Palmer; Katie L. Flanagan; William H. H. Reece; Kennedy Odhiambo; Kevin Marsh; Margaret Pinder; Michael B. Gravenor; Wendy A. Keitel; Kent E. Kester; Carter Diggs; David Kaslow; V. Apostolopoulos; W. Ripley Ballou; Adrian V. S. Hill; Urszula Krzych; Magdalena Plebanski

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Induction of T Helper Type 1 and 2 Responses to 19-Kilodalton Merozoite Surface Protein 1 in Vaccinated Healthy Volunteers and Adults Naturally Exposed to Malaria

机译：接种疫苗的健康志愿者和自然暴露于疟疾的成年人对19千达尔顿裂殖子表面蛋白1的T辅助类型1和2的诱导

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Plasmodium falciparum malaria is a major cause of death in the tropics. The 19-kDa subunit of P. falciparum merozoite surface protein 1 (MSP-1₁₉), a major blood stage vaccine candidate, is the target of cellular and humoral immune responses in animals and humans. In this phase I trial of MSP-1₁₉, immunization of nonexposed human volunteers with either of the two allelic forms of recombinant MSP-1₁₉ induced high levels of antigen-specific Th1 (gamma interferon) and Th2 (interleukin 4 [IL-4] and IL-10) type lymphokines. The adjustment of the antigen dose and number of immunizations regulated the level of specificity of immune responses and Th1/Th2 bias of responses induced by vaccination. Novel conserved and allelic T-cell epitopes which induced cross-strain immune responses were identified. Importantly, responses to many of these novel epitopes were also present in adults exposed to malaria, both in east (Kenya) and west Africa (The Gambia). These data suggest that epitope-specific naturally acquired MSP-1₁₉ immune responses in endemic populations can be boosted by vaccination.

机译：恶性疟原虫是热带地区的主要死因。 P P的19-kDa亚基。恶性疟原虫表面蛋白1（MSP-1 _{19 ）是主要的血液候选疫苗，是动物和人类细胞和体液免疫反应的靶标。在MSP-1 _{19 的I期临床试验中，用两种等位基因形式的重组MSP-1 _{19 中的任一种免疫未暴露的人类志愿者，诱导了高水平的抗原特异性Th1（γ干扰素）和Th2（白介素4 [IL-4]和IL-10）型淋巴因子。抗原剂量和免疫次数的调节调节了免疫应答的特异性水平和由疫苗诱导的应答的Th1 / Th2偏倚。确定了诱导交叉株免疫应答的新型保守和等位基因T细胞表位。重要的是，在东部（肯尼亚）和西非（冈比亚），暴露于疟疾的成年人中也存在对许多这些新颖表位的反应。这些数据表明，接种疫苗可以增强流行人群中表位特异性的自然获得性MSP-1 _{19 免疫应答。}}}} 展开▼

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《Infection and immunity》 |2002年第3期|共5页

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Edwin A. M. Lee; Dupeh R. Palmer; Katie L. Flanagan; William H. H. Reece; Kennedy Odhiambo; Kevin Marsh; Margaret Pinder; Michael B. Gravenor; Wendy A. Keitel; Kent E. Kester; Carter Diggs; David Kaslow; V. Apostolopoulos; W. Ripley Ballou; Adrian V. S. Hill; Urszula Krzych; Magdalena Plebanski;
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中图分类医学免疫学;

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1. An engineered Plasmodium falciparum C-terminal 19-kilodalton merozoite surface protein 1 vaccine candidate induces high levels of interferon-gamma production associated with cellular immune responses to specific peptide sequences in Gambian adults naturally exposed to malaria. [J] . Bisseye C, Yindom LM, Simpore J, Clinical and Experimental Immunology: An Official Journal of the British Society for Immunology . 2011,第3期

机译：在自然暴露于疟疾的冈比亚成年人中，工程化的恶性疟原虫C端19-千达尔顿裂殖子表面蛋白1疫苗候选物诱导了高水平的干扰素-γ产生，这与针对特定肽序列的细胞免疫反应有关。

2. Comparative analysis of the profiles of IgG subclass-specific responses to Plasmodium falciparum apical membrane antigen-1 and merozoite surface protein-1 in naturally exposed individuals living in malaria hypoendemic settings, Iran [J] . Maryam Rouhani, Sedigheh Zakeri, Akram A Mehrizi, Malaria Journal . 2015,第S1期

机译：伊朗疟疾低流行地区自然暴露个体对恶性疟原虫顶端膜抗原-1和裂殖子表面蛋白-1 IgG亚类特异性反应的特征的比较分析

3. Promiscuous T-cell epitopes of Plasmodium merozoite surface protein 9 (PvMSP9) induces IFN- gamma and IL-4 responses in individuals naturally exposed to malaria in the Brazilian Amazon. [J] . Lima Junior J. C., Banic D. M., Tran T. M., Vaccine . 2010,第18期

机译：疟原虫裂殖子表面蛋白9（PvMSP9）的混杂T细胞表位在巴西亚马逊地区自然暴露于疟疾的个体中诱导IFN-γ和IL-4反应。

4. Immunogenicity of Malaria Vaccine Candidate-Plasmodium falciparum Merozoite Surface Protein 5 (PfMSP5) Expressed in Bacillus subtilis [C] . Chittibabu Gottimukkala, Charles Ma, Hans J. Netter International Conference on Chemical, Biological and Environmental Engineering . 2014

机译：疟疾疫苗候选疟原虫的免疫原性是恶魔植物在枯草芽孢杆菌中表达的疟原虫候选疟原虫疟原虫表面蛋白5（PFMSP5）

5. The impact of the C-terminal conserved region of Plasmodium falciparum's merozoite surface protein-1 and within-host diversity on naturally acquired immunity to malaria. [D] . Branch, OraLee Hipp. 2001

机译：恶性疟原虫裂殖子表面蛋白-1的C端保守区和宿主内部多样性对自然获得的抗疟疾免疫力的影响。

6. Induction of T Helper Type 1 and 2 Responses to 19-Kilodalton Merozoite Surface Protein 1 in Vaccinated Healthy Volunteers and Adults Naturally Exposed to Malaria [O] . Edwin A. M. Lee, Dupeh R. Palmer, Katie L. Flanagan, 2002

机译：接种疫苗的健康志愿者和自然暴露于疟疾的成人对19千达尔顿裂殖子表面蛋白1的T辅助类型1和2的诱导

7. Induction of T helper type 1 and 2 responses to 19-kilodalton merozoite surface protein 1 in vaccinated healthy volunteers and adults naturally exposed to malaria. [O] . Lee, EA, Palmer, DR, Flanagan, KL, 2002

机译：在接种过疫苗的健康志愿者和自然暴露于疟疾的成年人中，对19千达尔顿裂殖子表面蛋白1的T辅助型1和2的诱导。

1. 恶性疟原虫裂殖子嵌合性表面蛋白疫苗诱导其高滴度生长抑制抗体 [J] . 陈锦荣(摘) ,江丽君(校) . 微生物学免疫学进展 . 2014,第005期

1. A FUSION PROTEIN MALARIA VACCINE CONSISTING OF PLASMODIUM FALCIPARUM MEROZOITE SURFACE PROTEIN 1 AND PLASMODIUM FALCIPARUM MEROZOITE SURFACE PROTEIN 3 [P] . 外国专利： IN282172B . 2017-04-07

机译：恶性疟原虫裂殖子表面蛋白1和恶性疟原虫裂殖子表面蛋白3的融合蛋白疟疾疫苗。

2. USE OF FUSION PROTEIN CONSISTING OF FRAGMENTS OF PLASMODIUM FALCIPARUM MEROZOITE SURFACE PROTEIN 1 AND PLASMODIUM FALCIPARUM MEROZOITE SURFACE PROTEIN 3 AS A MALARIA VACCINE [P] . 外国专利： IN2008DE01737A . 2010-04-23

机译：恶性疟原虫裂殖子表面蛋白1和恶性疟原虫裂殖子表面蛋白3片段的融合蛋白作为疟疾疫苗的应用

3. Vaccine comprises chimeric malaria proteins derived from Plasmodium falciparum genetically coupled to Plasmodium falcinarum Merozoite surface protein 3 [P] . 外国专利： DK200201741A . 2003-09-16

机译：疫苗包含源自恶性疟原虫的嵌合疟疾蛋白，该蛋白通过遗传与恶性疟原虫裂殖子表面蛋白3遗传偶联

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Induction of T Helper Type 1 and 2 Responses to 19-Kilodalton Merozoite Surface Protein 1 in Vaccinated Healthy Volunteers and Adults Naturally Exposed to Malaria

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