Naturally Attenuated, Orally Administered Mycobacterium microti as a Tuberculosis Vaccine Is Better than Subcutaneous Mycobacterium bovis BCG

Yukari C. Manabe; Cherise P. Scott; William R. Bishai

首页> 外文期刊>Infection and immunity >Naturally Attenuated, Orally Administered Mycobacterium microti as a Tuberculosis Vaccine Is Better than Subcutaneous Mycobacterium bovis BCG

【24h】

Naturally Attenuated, Orally Administered Mycobacterium microti as a Tuberculosis Vaccine Is Better than Subcutaneous Mycobacterium bovis BCG

机译：作为结核病疫苗，口服减毒的自然分枝杆菌比皮下牛分枝杆菌BCG更好

获取原文

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

Mycobacterium microti is phylogenetically closely related to Mycobacterium tuberculosis and is a member of that complex of organisms. It is a curved, acid-fast bacillus that is naturally attenuated with a narrow host range for Microtus species only. In this study, we confirm the unique susceptibility of voles to infection with M. microti and the relative resistance of mice with a significantly lower organism burden after 8 weeks of infection. In addition, histopathologic examination of lungs reveals a lack of cellular, granulomatous aggregates characteristically seen in murine M. tuberculosis infection. In the past, M. microti has been used successfully in humans as a vaccine against tuberculosis but was associated with cutaneous reactions. In an attempt to circumvent this adverse effect, we report the efficacy of aerosol and oral vaccination with M. microti. High-dose orogastric vaccination with M. microti resulted in a statistically significant improvement in protection against aerosol challenge with virulent M. tuberculosis in the murine model compared with subcutaneous M. bovis BCG Pasteur vaccination.

机译：微量分枝杆菌与结核分枝杆菌在系统发育上密切相关，并且是该生物群的成员。这是一种弯曲的，耐酸的芽孢杆菌，仅对 Microtus 物种具有较窄的宿主范围，可自然衰减。在这项研究中，我们证实了田鼠对 M感染的独特敏感性。感染后8周，微生物负荷显着降低的小鼠的微滴度和相对抗性。另外，肺的组织病理学检查显示缺乏在小鼠 M中特有的细胞性肉芽肿性聚集物。结核感染。过去， M。 microti 已成功用于人类作为抗结核疫苗，但与皮肤反应有关。为了避免这种不利影响，我们报告了气溶胶和 M口服疫苗的疗效。大剂量口服 M疫苗接种。微量的导致具有毒性的 M对气溶胶攻击的防护具有统计学上的显着改善。鼠模型中的肺结核与皮下 M相比。 Bovis BCG巴斯德疫苗接种。 展开▼

著录项

来源
《Infection and immunity》 |2002年第3期|共5页

作者
Yukari C. Manabe; Cherise P. Scott; William R. Bishai;
展开▼

作者单位

展开▼

收录信息

原文格式 PDF

正文语种

中图分类医学免疫学;

关键词

相似文献

外文文献

中文文献

专利

1. Loss of RD1 contributed to the attenuation of the live tuberculosis vaccines Mycobacterium bovis BCG and Mycobacterium microti. [J] . Pym AS, Brodin P, Brosch R, Molecular Microbiology . 2002,第3期

机译：RD1的丧失导致活结核疫苗牛分枝杆菌BCG和微量分枝杆菌的减弱。

2. Balancing Trained Immunity with Persistent Immune Activation and the Risk of Simian Immunodeficiency Virus Infection in Infant Macaques Vaccinated with Attenuated Mycobacterium tuberculosis or Mycobacterium bovis BCG Vaccine [J] . Kara Jensen, Myra Grace dela Pena-Ponce, Michael Piatak, Clinical and vaccine immunology: CVI . 2017,第1期

机译：在持续减毒的结核杆菌或牛分枝杆菌BCG疫苗接种的婴儿猕猴中，平衡训练有素的免疫力与持久性免疫活化和猿猴免疫缺陷病毒感染的风险

3. Comparison of the membrane proteome of virulent Mycobacterium tuberculosis and the attenuated Mycobacterium bovis BCG vaccine strain by label-free quantitative proteomics [J] . Gunawardena H.P., Feltcher M.E., Wrobel J.A., Journal of proteome research . 2013,第12期

机译：无标记定量蛋白质组学比较强毒结核分枝杆菌和减毒牛分枝杆菌卡介苗疫苗株的膜蛋白质组

4. Sodium Alginate as Stabilizer in Oral Delivery of Mycobacterium Bovis BCG [C] . F.Dobakhti, F.Rahimi, M. Taghikhani, Annual meeting exposition of the Controlled Release Society . 2005

机译：海藻酸钠作为牛分枝杆菌卡介苗口服给药的稳定剂

5. Characterization of major factors in the protective efficacy of a live attenuated vaccine against Mycobacterium tuberculosis using the naturally attenuated Mycobacterium microti in the murine model. [D] . Scott, Cherise P. 2005

机译：在鼠模型中，使用天然减毒的分枝杆菌可降低减毒活疫苗抵抗结核分枝杆菌的保护功效的主要因素。

6. Naturally Attenuated Orally Administered Mycobacterium microti as a Tuberculosis Vaccine Is Better than Subcutaneous Mycobacterium bovis BCG [O] . Yukari C. Manabe, Cherise P. Scott, William R. Bishai 2002

机译：作为结核病疫苗自然减毒口服小肠分枝杆菌优于皮下牛分枝杆菌BCG

7. Naturally Attenuated, Orally Administered Mycobacterium microti as a Tuberculosis Vaccine Is Better than Subcutaneous Mycobacterium bovis BCG [O] . Manabe, Yukari C., Scott, Cherise P., Bishai, William R. 2002

机译：作为结核病疫苗，自然减毒，口服的微量分枝杆菌优于皮下牛分枝杆菌卡介苗

1. 口服基于田鼠分枝杆菌的结核病疫苗效果优于BCG [J] . 陈锦荣 . 生物制品快讯 . 2003,第004期

2. 结核分枝杆菌活性减毒突变体——新型抗结核分枝杆菌候选疫苗 [J] . 汪海鹏 ,张雪莲 ,曹健 . 中国感染控制杂志 . 2006,第004期

3. 减毒结核分枝杆菌H37 Ra感染小鼠模型的实验研究 [J] . 张爱霞 ,江京娣 ,吕静竹 . 蚌埠医学院学报 . 2016,第002期

4. 结核分枝杆菌和牛分枝杆菌的二重PCR快速检测试剂盒的研究 [J] . 谢志勤 ,黄海强 ,谢芝勋 . 湖南农业科学 . 2010,第019期

5. 结核分枝杆菌与牛分枝杆菌全基因组比较分析 [J] . 朱汝仪 ,潘文 ,赵明秋 . 畜牧兽医学报 . 2010,第009期

6. 人结核分枝杆菌和牛分枝杆菌的宿主偏爱性 [C] . 刘进 ,赵德明 . 2012年中国畜牧兽医学会兽医病理学分会暨中国病理生理学会动物病理生理专业委员会学术研讨会 . 2012

7. 牛分枝杆菌感染巨噬细胞THP-1全基因表达谱变化与北京昌平结核分枝杆菌基因分型 [A] . 高峰 . 2008

1. 检测结核性分枝杆菌复合群和分枝杆菌属的组合物以及使用该组合物用多重实时PCR同时检测结核性分枝杆菌复合群和分枝杆菌属的方法 [P] . 中国专利： CN102471806B . 2015.06.03

2. 检测结核性分枝杆菌复合群和分枝杆菌属的组合物以及使用该组合物用多重实时PCR同时检测结核性分枝杆菌复合群和分枝杆菌属的方法 [P] . 中国专利： CN102471806A . 2012-05-23

3. BCG strain belonging to Mycobacterium bovis BCG Moreau strain, a pharmaceutical composition comprising Mycobacterium bovis belonging to Mycobacterium bovis BCG Moreau strain and method of preparing a pharmaceutical composition comprising the Mycobacterium bovis BCG strains belonging to Mycobacterium bovis BCG Moreau strain [P] . 外国专利： PL235706B1 . 2020-10-05

机译：属于牛分枝杆菌BCG Moreau菌株的BCG菌株，包含牛分枝杆菌BCG Moreau菌株的牛分枝杆菌的药物组合物和包含牛分枝杆菌BCG Moreau菌株的牛分枝杆菌BCG菌株的药物组合物的制备方法

4. BCG strain belonging to Mycobacterium bovis BCG Moreau strain, a pharmaceutical composition comprising Mycobacterium bovis belonging to Mycobacterium bovis BCG Moreau strain and method of preparing a pharmaceutical composition comprising the Mycobacterium bovis BCG strains belonging to Mycobacterium bovis BCG Moreau strain [P] . 外国专利： PL426164A1 . 2020-01-13

机译：属于牛分枝杆菌BCG Moreau菌株的BCG菌株，包含牛分枝杆菌BCG Moreau菌株的牛分枝杆菌的药物组合物和包含牛分枝杆菌BCG Moreau菌株的牛分枝杆菌BCG菌株的药物组合物的制备方法

5. A Diagnostic Kit for simultaneously detection of Clinical Strains of Mycobacterium tuberculosis, Mycobacterium bovis and/or Mycoabcterium bovis BCG and method using the same [P] . 外国专利： KR101512341B1 . 2015-04-15

机译：同时检测结核分枝杆菌，牛分枝杆菌和/或牛分枝杆菌卡介苗临床菌株的诊断试剂盒及其使用方法

相关主题

Naturally Attenuated, Orally Administered Mycobacterium microti as a Tuberculosis Vaccine Is Better than Subcutaneous Mycobacterium bovis BCG

摘要

著录项

相似文献

相关主题

期刊订阅