...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Infection and immunity >Temporal Analysis of Borrelia burgdorferi Erp Protein Expression throughout the Mammal-Tick Infectious Cycle
【24h】

Temporal Analysis of Borrelia burgdorferi Erp Protein Expression throughout the Mammal-Tick Infectious Cycle

机译：整个哺乳动物-ick虱感染周期中伯氏疏螺旋体Erp蛋白表达的时间分析

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Previous immunological studies indicated that the Lyme disease spirochete, Borrelia burgdorferi, expresses Erp outer surface proteins during mammalian infection. We conducted analyses of Erp expression throughout the entire tick-mammal infectious cycle, which revealed that the bacteria regulate Erp production in vivo. Bacteria within unfed nymphal ticks expressed little to no Erp proteins. However, as infected ticks fed on mice, B. burgdorferi increased production of Erp proteins, with essentially all transmitted bacteria expressing these proteins. Mice infected with B. burgdorferi mounted rapid IgM responses to all tested Erp proteins, followed by strong immunoglobulin G responses that generally increased in intensity throughout 11 months of infection, suggesting continued exposure of Erp proteins to the host immune system throughout chronic infection. As naive tick larvae acquired B. burgdorferi by feeding on infected mice, essentially all transmitted bacteria produced Erp proteins, also suggestive of continual Erp expression during mammalian infection. Shortly after the larvae acquired bacteria, Erp production was drastically downregulated. The expression of Erp proteins on B. burgdorferi throughout mammalian infection is consistent with their hypothesized function as factor H-binding proteins that protect the bacteria from host innate immune responses.
机译：先前的免疫学研究表明，莱姆病螺旋体 Borrelia burgdorferi 在哺乳动物感染过程中表达Erp外表面蛋白。我们在整个tick-哺乳动物感染周期中进行了Erp表达的分析，结果表明细菌在体内调节了Erp的产生。未进食的若虫壁虱中的细菌表达很少甚至没有Erp蛋白。但是，作为感染的s虫以小鼠为食， B。 burgdorferi 增加了Erp蛋白的产量，基本上所有传播的细菌都表达这些蛋白。感染了 B的小鼠。 burgdorferi 对所有测试的Erp蛋白均具有快速的IgM反应，随后是强烈的免疫球蛋白G反应，通常在感染11个月后强度增强，这表明在整个慢性感染中Erp蛋白仍持续暴露于宿主免疫系统。由于幼稚的tick幼虫获得了 B。通过以感染的小鼠为食，burgdorferi 基本上所有传播的细菌都会产生Erp蛋白，这也暗示了哺乳动物感染过程中Erp的持续表达。幼虫获得细菌后不久，Erp的产量就大大降低了。 Erp蛋白在 B上的表达。在整个哺乳动物感染过程中，burgdorferi 与它们作为因子H结合蛋白的假想功能相符，可以保护细菌免受宿主固有的免疫反应。

著录项

相似文献

  • 外文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号