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首页> 外文期刊>Infection and immunity >Characterization of Antibody Responses to Wolbachia Surface Protein in Humans with Lymphatic Filariasis
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Characterization of Antibody Responses to Wolbachia Surface Protein in Humans with Lymphatic Filariasis

机译：淋巴丝虫病患者对Wolbachia表面蛋白抗体应答的表征。

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Symbiotic Wolbachia organisms of filarial nematodes have received much attention as possible chemotherapy targets and disease-causing organisms. In order to further investigate the association between anti-Wolbachia immune responses and chronic filarial disease in humans, antibody responses to Wolbachia surface protein (WSP) were assayed in serum samples collected from 232 individuals living in Leogane, Haiti, an area where Wuchereria bancrofti infection is endemic, and from 67 North Americans with no history of lymphatic filariasis. As opposed to antifilarial antibody responses, which were largely influenced by the patient's infection status, the prevalence and levels of anti-WSP immunoglobulin G (IgG) antibodies among individuals with lymphedema or hydrocele were significantly greater than those in gender- and infection-matched individuals without disease. In at least one case, the anti-WSP IgG response was coincident with the onset of lymphedema development, and among anti-WSP-positive women with lymphedema, anti-WSP IgG levels were negatively correlated with the duration of lymphedema. The presence of anti-WSP IgG was also associated with the severity of inguinal adenopathy among men with hydrocele. In addition to the presence of anti-WSP antibodies among Haitians, 15 of 67 (22%) serum samples collected from individuals from North America, where filariasis is not endemic, were also positive for anti-WSP antibodies. In comparison to those from Haitians, anti-WSP antibodies from North Americans primarily recognized a distinct region of WSP located within the highly conserved second transmembrane domain. The results of this study demonstrate that anti-WSP antibody responses are associated with the presence of chronic filarial morbidity and not filarial infection status in humans and suggest that WSP should be further studied as a potential trigger for the development of filarial disease.
机译：丝状线虫的共生生物作为可能的化疗靶标和致病生物受到了广泛关注。为了进一步研究人类的抗免疫应答与慢性丝虫病之间的关系，在收集的血清样本中测定了对 Wolbachia 表面蛋白（WSP）的抗体应答居住在海地Leogane的232人，来自67名没有淋巴丝虫病病史的北美地区，是地方性Wuchereria bancrofti 流行的地方。与受患者感染状况影响很大的抗丝虫抗体反应相反，淋巴水肿或鞘膜积液患者中抗WSP免疫球蛋白G（IgG）抗体的发生率和水平显着高于性别和感染匹配者没有疾病。在至少一种情况下，抗WSP IgG反应与淋巴水肿的发生相吻合，在患有淋巴水肿的抗WSP阳性女性中，抗WSP IgG水平与淋巴水肿的持续时间呈负相关。抗WSP IgG的存在也与鞘膜积液男性腹股沟腺病的严重程度有关。除了在海地人中存在抗​​WSP抗体外，从非丝虫病流行地区的北美人群收集的67个血清样本中有15个（占22％）血清中的抗WSP抗体也呈阳性。与海地人相比，北美人的抗WSP抗体主要识别WSP的一个独特区域，该区域位于高度保守的第二跨膜结构域内。这项研究的结果表明，抗WSP抗体应答与人类中慢性丝虫病的发病率相关，而不与丝虫感染状态有关，并建议应进一步研究WSP作为丝虫病发展的潜在诱因。

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