• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Infection and immunity >Vaccination with Attenuated Neisseria meningitidis Strains Protects against Challenge with Live Meningococci
【24h】

Vaccination with Attenuated Neisseria meningitidis Strains Protects against Challenge with Live Meningococci

机译：减毒脑膜炎奈瑟氏球菌疫苗接种可预防活脑膜炎球菌

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Meningococcal disease is a life-threatening infection caused by Neisseria meningitidis. Currently, there are no vaccines to prevent infection with serogroup B N. meningitidis strains, the leading cause of meningococcal meningitis in Europe and North America. Here we describe the construction and characterization of two attenuated serogroup B N. meningitidis strains, YH102 (MC58Δsia ΔrfaF) and YH103 (MC58Δsia ΔmetH). Both strains are markedly attenuated in their capacity to cause bacteremia in rodent models and have a reduced ability to survive in a human whole-blood assay. Immunization of adult mice with these strains leads to the development of bactericidal antibodies and confers sterilizing protection against challenge with homologous live bacteria. Furthermore, we show that the strains confer protection against infection by other serogroups. Use of the attenuated strains in animals with gene knockouts or after depletion of immunological effectors could be used to define the basis of protection, and human volunteer studies could be undertaken to examine the immune response following exposure to this important human pathogen.
机译：脑膜炎球菌病是由脑膜炎奈瑟氏球菌引起的威胁生命的感染。当前，没有疫苗可预防B群 N感染。脑膜炎菌株，是欧洲和北美脑膜炎球菌性脑膜炎的主要原因。在这里，我们描述了两个减毒血清型B N的构建和表征。脑膜炎菌株，YH102（MC58Δ sia Δ rfaF ）和YH103（MC58Δ sia Δ metH ） 。两种菌株在啮齿动物模型中引起菌血症的能力均显着减弱，并且在人全血试验中的存活能力降低。用这些菌株免疫成年小鼠会导致杀菌抗体的产生，并赋予杀菌保护以抵抗同源活细菌的攻击。此外，我们表明该菌株可防止其他血清群感染。减毒株在基因敲除或免疫效应耗尽后的动物中的使用可用于定义保护的基础，并且可进行人类志愿者研究以检查暴露于这种重要人类病原体后的免疫反应。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号