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首页> 外文期刊>Infection and immunity >Probiotic Lactobacillus reuteri Ameliorates Disease Due to Enterohemorrhagic Escherichia coli in Germfree Mice
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Probiotic Lactobacillus reuteri Ameliorates Disease Due to Enterohemorrhagic Escherichia coli in Germfree Mice

机译：益生菌罗伊氏乳杆菌改善了无菌性小鼠肠出血性大肠杆菌引起的疾病

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摘要

Strains of enterohemorrhagic Escherichia coli (EHEC) are a group of Shiga toxin-producing food-borne pathogens that cause severe hemorrhagic colitis and can lead to hemolytic-uremic syndrome (HUS), a life-threatening condition that principally affects children and for which there is no effective treatment. We used a germfree mouse model of renal and enteric disease due to EHEC to determine if probiotic Lactobacillus reuteri ATCC PTA 6475 is effective in suppressing disease symptoms caused by EHEC. When germfree Swiss Webster mice are monocolonized with EHEC, they develop disease characterized by weight loss, cecal luminal fluid accumulation, and renal tubular necrosis. When L. reuteri was administered 1 day prior to EHEC challenge and every other day thereafter, EHEC colonization was suppressed and mice were significantly protected from the manifestations of disease. Protection from disease did not require the induction of the antimicrobial compound reuterin in L. reuteri prior to treatment. The twice-daily administration of L. reuteri appeared more effective than every-other-day administration. These data indicated that L. reuteri partially protects mice from disease manifestations of EHEC.
机译：肠出血性大肠埃希菌（EHEC）菌株是一组产生志贺毒素的食源性病原体，可导致严重的出血性结肠炎，并可导致溶血性尿毒症综合征（HUS），这是一种危及生命的疾病，主要影响儿童，没有有效的治疗方法。我们使用了因EHEC引起的肾脏和肠道疾病的无菌小鼠模型，以确定益生菌罗伊氏乳杆菌 ATCC PTA 6475是否有效抑制EHEC引起的疾病症状。当无菌的Webster小鼠与EHEC进行单菌落化时，它们会发展出以体重减轻，盲肠腔积液和肾小管坏死为特征的疾病。当 L。在接受EHEC攻击前1天施用罗伊特氏菌，此后每隔一天注射一次，可抑制EHEC的定植，并显着保护小鼠免受疾病侵袭。保护免受疾病并不需要诱导 L中的抗菌化合物罗伊特林。罗伊特病。 L每天两次给药。罗伊特氏菌似乎比隔日给药更有效。这些数据表明 L。罗伊特氏菌可以部分保护小鼠免受EHEC疾病的侵害。

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