...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Infection and immunity >Oral Exposure to Trypanosoma cruzi Elicits a Systemic CD8+ T Cell Response and Protection against Heterotopic Challenge
【24h】

Oral Exposure to Trypanosoma cruzi Elicits a Systemic CD8+ T Cell Response and Protection against Heterotopic Challenge

机译：克鲁氏锥虫的口服暴露引发系统性CD8 + T细胞应答并抵抗异位攻击

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Trypanosoma cruzi infects millions of people in Latin America and often leads to the development of Chagas disease. T. cruzi infection can be acquired at or near the bite site of the triatomine vector, but per os infection is also a well-documented mode of transmission, as evidenced by recent microepidemics of acute Chagas disease attributed to the consumption of parasite-contaminated foods and liquids. It would also be convenient to deliver vaccines for T. cruzi by the oral route, particularly live parasite vaccines intended for the immunization of reservoir hosts. For these reasons, we were interested in better understanding immunity to T. cruzi following oral infection or oral vaccination, knowing that the route of infection and site of antigen encounter can have substantial effects on the ensuing immune response. Here, we show that the route of infection does not alter the ability of T. cruzi to establish infection in muscle tissue nor does it impair the generation of a robust CD8+ T cell response. Importantly, oral vaccination with attenuated parasites provides protection against wild-type (WT) T. cruzi challenge. These results strongly support the development of whole-organism-based vaccines targeting reservoir species as a means to alleviate the burden of Chagas disease in affected regions.
机译：克鲁氏锥虫感染拉丁美洲数百万人，并经常导致南美锥虫病的发展。克鲁维氏锥虫感染可在三atomine载体的咬合位点或其附近获得，但是 per os 感染也是一种有据可查的传播方式，最近因急性查加斯病引起的微流行病证明了这一点。食用被寄生虫污染的食品和液体。通过口服途径递送克氏锥虫的疫苗也将是方便的，特别是打算用于免疫宿主宿主的活寄生虫疫苗。由于这些原因，我们有兴趣更好地了解口服感染或口服疫苗接种后对克氏锥虫的免疫力，因为他们知道感染的途径和抗原遇到的部位会对随后的免疫反应产生实质性影响。在这里，我们表明感染的途径不会改变克鲁氏梭菌在肌肉组织中建立感染的能力，也不会损害坚固的CD8 + T细胞反应的产生。重要的是，口服减毒寄生虫疫苗可提供针对野生型（WT）克氏锥虫攻击的保护作用。这些结果有力地支持了针对以水库物种为目标的全生物疫苗的开发，以减轻受影响地区南美锥虫病的负担。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号