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首页> 外文期刊>Infection and immunity >PPE38 Modulates the Innate Immune Response and Is Required for Mycobacterium marinum Virulence
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PPE38 Modulates the Innate Immune Response and Is Required for Mycobacterium marinum Virulence

机译：PPE38调节先天性免疫反应，是海洋分枝杆菌毒力所必需的

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The proline-glutamic acid (PE) and proline-proline-glutamic acid (PPE) family proteins are prevalent in pathogenic mycobacteria and play a diverse role in mycobacterial pathogenesis. While some members have been studied, the function of most PE/PPE proteins remains unknown. In this study, we isolated a transposon-inactivated PPE38 mutant of Mycobacterium marinum and characterized its phenotype. We found that the PPE38 protein is associated with the cell wall and exposed on the cell surface. The inactivation of PPE38 altered the bacterial cell surface properties and led to deficiencies in cord formation, sliding motility, and biofilm formation. The PPE38 mutant was defective in phagocytosis by macrophages and exhibited reduced virulence in adult zebrafish. We also found that PPE38 is involved in the induction of proinflammatory cytokines in infected macrophages. Together, our results indicate that PPE38, a previously uncharacterized protein, plays a role in mycobacterial virulence, presumably by modulating the host innate immune response.
机译：脯氨酸-谷氨酸（PE）和脯氨酸-脯氨酸-谷氨酸（PPE）家族蛋白在致病性分枝杆菌中普遍存在，并在分枝杆菌的发病机理中发挥多种作用。尽管已经研究了一些成员，但大多数PE / PPE蛋白的功能仍然未知。在这项研究中，我们分离了转座子灭活的海洋分枝杆菌 PPE38 突变体并表征了其表型。我们发现PPE38蛋白与细胞壁相关并暴露在细胞表面。 Pem38 的失活改变了细菌的细胞表面特性，并导致脐带形成，滑动运动和生物膜形成方面的缺陷。 PPE38 突变体在巨噬细胞吞噬作用方面存在缺陷，并且在成年斑马鱼中显示出降低的毒力。我们还发现，PPE38参与了感染巨噬细胞中促炎细胞因子的诱导。总之，我们的结果表明，以前未知的蛋白PPE38在分枝杆菌毒力中起作用，大概是通过调节宿主的先天免疫应答。

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