首页> 外文期刊>Infection and immunity >In Vivo Adaptation of the Wayne Model of Latent Tuberculosis
【24h】

In Vivo Adaptation of the Wayne Model of Latent Tuberculosis

机译:潜伏性结核韦恩模型的体内适应

获取原文
           

摘要

Cultures of Mycobacterium tuberculosis grown under oxygen depletion conditions enter into a state of nonreplicating persistence that may reflect a physiologically latent state. When these cultures were harvested and injected intranasally into mice, no bacteria could be recovered from the lungs for about 3 weeks, but after that evidence of regrowth was observed. Preimmunization of mice with a panel of selected vaccine candidates slowed or prevented this event. This simple model has potential for identifying vaccines targeting latent tuberculosis.
机译:在耗氧条件下生长的结核分枝杆菌培养物进入非复制性持久状态,这可能反映出生理上的潜在状态。当收集这些培养物并将其鼻内注射到小鼠中时,大约3周内无法从肺中回收细菌,但是在此之后观察到了再生的迹象。用一组选定的候选疫苗对小鼠进行预免疫可以减缓或预防此事件。这个简单的模型具有识别潜在结核病疫苗的潜力。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号