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首页> 外文期刊>Infection and immunity >Transcription Factor PrtT Controls Expression of Multiple Secreted Proteases in the Human Pathogenic Mold Aspergillus fumigatus
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Transcription Factor PrtT Controls Expression of Multiple Secreted Proteases in the Human Pathogenic Mold Aspergillus fumigatus

机译：转录因子PrtT控制人类致病性模具烟曲霉中多种分泌蛋白酶的表达。

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摘要

The role of secreted proteases in the virulence of the pathogenic fungus Aspergillus fumigatus remains controversial. Recently, the Aspergillus niger transcription factor PrtT was shown to control the expression of multiple secreted proteases. In this work, the gene which encodes the PrtT homolog in A. fumigatus was cloned and its function analyzed using a deletion mutant strain. Deletion of A. fumigatus prtT resulted in the loss of secreted protease activity. The expression of six secreted proteases (ALP, MEP, Dpp4, CpdS, AFUA_2G17330, and AFUA_7G06220) was markedly reduced. Culture filtrates from the prtT deletion strain exhibited reduced killing of lung epithelial cells and lysis of erythrocytes. However, the prtT deletion strain did not exhibit altered virulence in lung-infected mice. These results suggest that PrtT is not a significant virulence factor in A. fumigatus.
机译：分泌的蛋白酶在致病性真菌烟曲霉的毒性中的作用仍存在争议。最近，显示了黑曲霉转录因子PrtT可控制多种分泌蛋白酶的表达。在这项工作中，在 A中编码PrtT同源物的基因。克隆了烟熏，并使用缺失突变株对其功能进行了分析。删除 A。烟的rtt 导致分泌的蛋白酶活性丧失。六个分泌的蛋白酶（ALP，MEP，Dpp4，CpdS，AFUA_2G17330和AFUA_7G06220）的表达显着降低。来自 prtT 缺失菌株的培养滤液显示出减少的肺上皮细胞杀伤和红细胞溶解。但是， prtT 缺失株在肺部感染的小鼠中并未显示出改变的毒力。这些结果表明PrtT不是 A中的重要毒力因子。烟熏。

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