Delivery of the Immunosuppressive Antigen Salp15 to Antigen-Presenting Cells by Salmonella enterica Serovar Typhimurium aroA Mutants

Amir-Reza T. Motameni; Ignacio J. Juncadella; Shobana K. Ananthanarayanan; Michael N. Hedrick; Yvette Huet-Hudson; Juan Anguita

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Delivery of the Immunosuppressive Antigen Salp15 to Antigen-Presenting Cells by Salmonella enterica Serovar Typhimurium aroA Mutants

机译：肠炎沙门氏菌血清鼠伤寒沙门氏菌aroA突变体将免疫抑制抗原Salp15递送至抗原呈递细胞。

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A Salmonella enterica serovar Typhimurium aroA-deficient delivery system was used to target the immunosuppressive protein Salp15 to antigen-presenting cells. In vitro and in vivo infections with Salp15-containing Salmonella resulted in an impaired CD4+-T-cell activation, suggesting that the protein was produced by antigen-presenting cells in a physiologically active form.

机译：使用沙门氏菌血清型鼠伤寒 aroA 缺陷型递送系统将免疫抑制蛋白Salp15靶向抗原呈递细胞。含Salp15的 Salmonella 的体外和体内感染导致CD4 + -T细胞活化受损，这表明该蛋白是由抗原呈递细胞产生的。生理活性形式。 展开▼

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《Infection and immunity》 |2004年第6期|共5页

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Amir-Reza T. Motameni; Ignacio J. Juncadella; Shobana K. Ananthanarayanan; Michael N. Hedrick; Yvette Huet-Hudson; Juan Anguita;
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中图分类医学免疫学;

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1. Comparison of Abilities of Salmonella enterica Serovar Typhimurium aroA aroD and aroA htrA Mutants To Act as Live Vectors [J] . Mark Roberts, Steven Chatfield, Derek Pickard, Infection and immunity . 2000,第10期

机译：鼠伤寒沙门氏菌鼠伤寒杆菌aroA aroD和aroA htrA突变体作为活载体的能力比较

2. Comparison of Abilities of Salmonella enterica Serovar Typhimurium aroA aroD and aroA htrA Mutants To Act as Live Vectors [J] . Mark Roberts, Steven Chatfield, Derek Pickard, Infection and immunity . 2000,第10期

机译：鼠伤寒沙门氏菌鼠伤寒杆菌aroA aroD和aroA htrA突变体作为活载体的能力比较

3. Genetic detoxification of an aroA Salmonella enterica serovar Typhimurium vaccine strain does not compromise protection against virulent Salmonella and enhances the immune responses towards a protective malarial antigen. [J] . McKelvie ND, Khan SA, Karavolos MH, FEMS immunology and medical microbiology . 2008,第2期

机译：aroA肠炎沙门氏菌鼠伤寒沙门氏菌疫苗株的遗传解毒不会损害针对强毒沙门氏菌的保护，不会增强对保护性疟疾抗原的免疫反应。

4. Rapid identification of Salmonella enterica serovars Typhi and Salmonella enterica serovars Paratyphi A from chicken meat [C] . D Raharjo, R Yulistiani, W Setyarini International Conference on Food Science and Engineering . 2020

机译：来自鸡肉肉的沙门氏菌肠道塞洛维拉斯塞洛尼察塞洛维拉斯柳树和沙门氏菌肠道甲虫帕拉替米来

5. Microbiome and Immune Response to Salmonella enterica Serovar Typhimurium and Lawsonia intracellularis Infection in Swine [D] . Leivas Leite, Fernando Lopes. 2018

机译：猪对肠道沙门氏菌血清鼠伤寒和胞内劳森菌感染的微生物组和免疫反应

6. Delivery of the Immunosuppressive Antigen Salp15 to Antigen-Presenting Cells by Salmonella enterica Serovar Typhimurium aroA Mutants [O] . Amir-Reza T. Motameni, Ignacio J. Juncadella, Shobana K. Ananthanarayanan, 2004

机译：通过肠沙门氏菌血清型鼠伤寒沙门氏菌aroA突变体将免疫抑制抗原Salp15递送至抗原呈递细胞。

7. Delivery of the Immunosuppressive Antigen Salp15 to Antigen-Presenting Cells by Salmonella enterica Serovar Typhimurium aroA Mutants [O] . Motameni, Amir-Reza T., Juncadella, Ignacio J., Ananthanarayanan, Shobana K., 2004

机译：通过肠沙门氏菌血清型鼠伤寒沙门氏菌aroA突变体将免疫抑制抗原Salp15递送至抗原呈递细胞。

1. 血清癌胚抗原与免疫抑制酸性蛋白联合检测对大肠癌诊断价值的探讨 [J] . 王剑 ,聂绍发 ,朱桂宝 . 检验医学 . 2005,第003期

1. 用抗血清筛选插入突变体文库鉴定抗原性重要的奈瑟氏球菌属抗原 [P] . 中国专利： CN1925888A . 2007-03-07

2. Use of Salmonella enterica ssp. enterica serovar Typhimurium antigens for serological differentiation of infected and vaccinated pigs [P] . 外国专利： CZ20131048A3 . 2015-04-22

机译：使用沙门氏菌小肠沙门氏菌。肠炎血清鼠伤寒抗原用于感染猪和疫苗接种猪的血清学区分

3. Use of Salmonella enterica ssp. enterica serovar Typhimurium antigens for serological differentiation of infected and vaccinated pigs [P] . 外国专利： CZ305077B6 . 2015-04-22

机译：使用沙门氏菌小肠沙门氏菌。肠炎血清鼠伤寒抗原用于感染猪和疫苗接种猪的血清学区分

4. typhimurium Salmonella enterica serotype 1.2 having cross reactivity with Salmonella enterica serotype 4,5,12: a specific monoclonal antibody against antigen h i: - producing cell line and its use. [P] . 外国专利： ES2349204B1 . 2011-11-15

机译：鼠伤寒沙门氏菌血清型1.2与肠炎沙门氏菌血清型4,5,12具有交叉反应性：一种针对产生抗原的细胞株的特异性单克隆抗体及其用途。

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Delivery of the Immunosuppressive Antigen Salp15 to Antigen-Presenting Cells by Salmonella enterica Serovar Typhimurium aroA Mutants

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