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首页> 外文期刊>Infection and immunity >Determination of the Relationship between Group A Streptococcal Genome Content, M Type, and Toxic Shock Syndrome by a Mixed Genome Microarray
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Determination of the Relationship between Group A Streptococcal Genome Content, M Type, and Toxic Shock Syndrome by a Mixed Genome Microarray

机译：混合基因组微阵列测定A组链球菌基因组含量，M型与毒性休克综合征之间的关系

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Group A streptococci (GAS), or Streptococcus pyogenes, are associated with a remarkable variety of diseases, ranging from superficial infections to life-threatening diseases such as toxic-shock-like syndrome (TSS). GAS strains belonging to M types M1 and M3 are associated with TSS. This study aims to obtain insight into the gene profiles underlying different M types and disease manifestations. Genomic differences between 76 clinically well characterized GAS strains collected in The Netherlands were examined using a mixed-genome microarray. Inter-M-type genomic differences clearly outweighed intra-M-type genome variation. Phages were major contributors to observed genome diversification. We identified four novel genes, including two genes encoding fibronectin-binding-like proteins, which are highly specific to a subset of M types and thus may contribute to M-type-associated disease manifestations. All M12 strains were characterized by the unique absence of the citrate lyase complex and reduced growth under hypoxic, nutrient-deprived conditions. Furthermore, six virulence factors, including genes encoding a complement-inhibiting protein (sic), an exotoxin (speA), iron(III) binding factor, collagen binding factor (cpa), and fibrinogen binding factor (prt2-like), were unique to M1 and/or M3 strains. These virulence factors may contribute to the potential of these strains to cause TSS. Finally, in contrast to M-type-specific virulence profiles, we did not identify a common virulence profile among strains associated with TSS irrespective of their M type.
机译：A组链球菌（GAS）或化脓性链球菌（emem）与各种各样的疾病有关，从表面感染到威胁生命的疾病，如中毒性休克样综合征（TSS）。属于M型M1和M3的GAS菌株与TSS相关。这项研究旨在深入了解不同M类型和疾病表现的基因概况。使用混合基因组微阵列检查了荷兰收集的76种临床特征良好的GAS菌株之间的基因组差异。 M型之间的基因组差异明显大于M型内部的基因组变异。噬菌体是观察到的基因组多样化的主要贡献者。我们鉴定了四个新基因，包括两个编码纤连蛋白结合样蛋白的基因，它们对M型子集具有高度特异性，因此可能与M型相关的疾病表现有关。所有M12菌株的特征是柠檬酸裂解酶复合物的独特缺失，并且在缺氧，营养缺乏的条件下生长减少。此外，六种毒力因子包括编码补体抑制蛋白（ sic ），外毒素（ speA ），铁（III）结合因子，胶原结合因子（< em> cpa ）和纤维蛋白原结合因子（ prt2-like ）对于M1和/或M3菌株是唯一的。这些毒力因子可能有助于这些菌株引起TSS。最后，与M型特异性毒力谱相反，我们未发现与TSS相关的菌株之间的通用毒谱，无论其M型如何。

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