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首页> 外文期刊>Infection and immunity >Six Genes Are Preferentially Transcribed by the Circulating and Sequestered Forms of Plasmodium falciparum Parasites That Infect Pregnant Women
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Six Genes Are Preferentially Transcribed by the Circulating and Sequestered Forms of Plasmodium falciparum Parasites That Infect Pregnant Women

机译：通过循环和隔离形式感染孕妇的恶性疟原虫的寄生形式优先转录六个基因。

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In areas of stable malaria transmission, susceptibility to Plasmodium falciparum malaria increases during first pregnancy. Women become resistant to pregnancy malaria over successive pregnancies as they acquire antibodies against the parasite forms that sequester in the placenta, suggesting that a vaccine is feasible. Placental parasites are antigenically distinct and bind receptors, like chondroitin sulfate A (CSA), that are not commonly bound by other parasites. We used whole-genome-expression analysis to find transcripts that distinguish parasites of pregnant women from other parasites and employed a novel approach to define and adjust for cell cycle timing of parasites. Transcription of six genes was substantially higher in both placental parasites and peripheral parasites from pregnant women, and each gene encodes a protein with a putative export sequence and/or transmembrane domain. This cohort of genes includes var2csa, a member of the variant PfEMP1 gene family previously implicated in pregnancy malaria, as well as five conserved genes of unknown functions. Women in East Africa acquire antibodies over successive pregnancies against a protein encoded by one of these genes, PFD1140w, and this protein shows seroreactivity similar to that of VAR2CSA domains. These findings suggest that a suite of genes may be important for the genesis of the placental binding phenotype of P. falciparum and may provide novel targets for therapeutic intervention.
机译：在疟疾传播稳定的地区，第一次怀孕期间，对恶性疟原虫疟疾的易感性增加。随着妇女获得针对隔离在胎盘中的寄生虫形式的抗体，妇女在连续怀孕后变得对妊娠疟疾具有抵抗力，这表明疫苗是可行的。胎盘寄生虫在抗原上是不同的并且结合受体，例如硫酸软骨素A（CSA），通常不与其他寄生虫结合。我们使用全基因组表达分析来找到可将孕妇的寄生虫与其他寄生虫区分开的转录本，并采用新颖的方法来定义和调整寄生虫的细胞周期。在孕妇的胎盘寄生虫和外周寄生虫中，六个基因的转录均显着较高，并且每个基因编码具有推定输出序列和/或跨膜结构域的蛋白质。该基因组包括 var2csa ，先前与妊娠疟疾有关的PfEMP1基因变异家族的成员，以及五个功能未知的保守基因。东非妇女在连续妊娠中获得针对这些基因之一编码的蛋白质 PFD1140w 的抗体，该蛋白质的血清反应性与VAR2CSA结构域相似。这些发现表明，一组基因对于 P的胎盘结合表型的发生可能是重要的。并可能为治疗干预提供新的靶点。

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