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首页> 外文期刊>Infection and immunity >Distinctive Profiles of Infection and Pathology in Hamsters Infected with Clostridium difficile Strains 630 and B1
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Distinctive Profiles of Infection and Pathology in Hamsters Infected with Clostridium difficile Strains 630 and B1

机译：难辨梭状芽孢杆菌630和B1感染仓鼠的感染和病理学特征

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Currently, the Golden Syrian hamster is widely considered an important model of Clostridium difficile disease, as oral infection of this animal pretreated with antibiotics reproduces many of the symptoms observed in humans. Two C. difficile strains, B1 and 630, showed significant differences in the progression and severity of disease in this model. B1-infected hamsters exhibited more severe pathology and a shorter time to death than hamsters infected with 630. Histological changes in the gut did not correlate with absolute numbers of C. difficile bacteria, but there were clear differences in the distribution of bacteria within gut tissues. Light, scanning, and transmission electron microscopy revealed high numbers of B1 bacteria at the mucosal surface of the tissue, whereas 630 bacteria were more frequently associated with the crypt regions. Both B1 and 630 bacteria were frequently observed within polymorphonuclear leukocytes, although, interestingly, a space frequently separated B1 bacteria from the phagosome wall, a phenomenon not observed with 630. However, pilus-like structures were detected on 630 located in the crypts of the gut tissue. Furthermore, B1 bacteria, but not 630 bacteria, were found within nonphagocytic cells, including enterocytes and muscle cells.
机译：当前，金叙利亚仓鼠被广泛认为是艰难梭菌疾病的重要模型，因为用抗生素预处理的这种动物的口腔感染重现了人类观察到的许多症状。两个 C。在该模型中，艰难梭菌B1和630在疾病的进展和严重程度上显示出显着差异。 B1感染的仓鼠比630感染的仓鼠表现出更严重的病理学和更短的死亡时间。肠道中的组织学变化与 C的绝对数量无关。细菌，但肠道组织中细菌的分布存在明显差异。光，扫描和透射电镜观察到，在组织的粘膜表面有大量的B1细菌，而630个细菌更常与隐窝区域相关。虽然有趣的是，一个空间经常将B1细菌与吞噬体壁分隔开，但在630多态核白细胞中经常观察到B1和630细菌，但630却未观察到这种现象。但是，在B1和630隐窝的630处发现了菌毛状结构。肠组织。此外，在非吞噬细胞（包括肠上皮细胞和肌肉细胞）中发现了B1细菌，但没有630细菌。

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