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首页> 外文期刊>Infection and immunity >Nucleoside Diphosphate Kinase and Flagellin from Pseudomonas aeruginosa Induce Interleukin 1 Expression via the Akt/NF-κB Signaling Pathways
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Nucleoside Diphosphate Kinase and Flagellin from Pseudomonas aeruginosa Induce Interleukin 1 Expression via the Akt/NF-κB Signaling Pathways

机译：铜绿假单胞菌的核苷二磷酸激酶和鞭毛蛋白通过Akt /NF-κB信号通路诱导白介素1表达。

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摘要

Inflammatory responses are a first line of host defense against a range of invading pathogens, consisting of the release of proinflammatory cytokines followed by attraction of polymorphonuclear neutrophils (PMNs) to the site of inflammation. Among the many virulence factors that contribute to the pathogenesis of infections, nucleoside diphosphate kinase (Ndk) mediates bacterially induced toxicity against eukaryotic cells. However, no study has examined how Ndk affects inflammatory responses. The present study examined the mechanisms by which Pseudomonas aeruginosa activates inflammatory responses upon infection of cells. The results showed that bacterial Ndk, with the aid of an additional bacterial factor, flagellin, induced expression of the proinflammatory cytokines interleukin-1α (IL-1α) and IL-1β. Cytokine induction appeared to be dependent on the kinase activity of Ndk and was mediated via the NF-κB signaling pathway. Notably, Ndk activated the Akt signaling pathway, which acts upstream of NF-κB, as well as caspase-1, which is a key component of inflammasome. Thus, this study demonstrated that P. aeruginosa, through the combined effects of Ndk and flagellin, upregulates the expression of proinflammatory cytokines via the Akt/NF-κB signaling pathways.
机译：炎症反应是宿主防御一系列入侵病原体的第一道防线，包括释放促炎细胞因子，然后将多形核中性粒细胞（PMN）吸引到炎症部位。在导致感染发病机理的许多毒力因子中，核苷二磷酸激酶（Ndk）介导细菌诱导的对真核细胞的毒性。但是，没有研究检查Ndk如何影响炎症反应。本研究检查了铜绿假单胞菌感染细胞后激活炎症反应的机制。结果表明，细菌Ndk借助另外的细菌因子鞭毛蛋白诱导促炎细胞因子白介素1α（IL-1α）和IL-1β的表达。细胞因子的诱导似乎依赖于Ndk的激酶活性，并通过NF-κB信号传导途径介导。值得注意的是，Ndk激活了Akt信号通路，该通路在NF-κB的上游起作用，而caspase-1则是炎症小体的关键成分。因此，这项研究表明铜绿假单胞菌通过Ndk和鞭毛蛋白的联合作用，通过Akt /NF-κB信号通路上调了促炎细胞因子的表达。

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