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首页> 外文期刊>Infection and immunity >Mycobacterium-Specific γ9δ2 T Cells Mediate Both Pathogen-Inhibitory and CD40 Ligand-Dependent Antigen Presentation Effects Important for Tuberculosis Immunity
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Mycobacterium-Specific γ9δ2 T Cells Mediate Both Pathogen-Inhibitory and CD40 Ligand-Dependent Antigen Presentation Effects Important for Tuberculosis Immunity

机译：分枝杆菌特异性γ9δ2T细胞介导对结核病免疫重要的病原体抑制和CD40配体依赖性抗原呈递作用

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Numerous pathogens, including Mycobacterium tuberculosis, can activate human γ9δ2 T cells to proliferate and express effector mechanisms. γ9δ2 T cells can directly inhibit the growth of intracellular mycobacteria and may also act as antigen-presenting cells (APC). Despite evidence for γδ T cells having the capacity to function as APC, the mechanisms involved and importance of these effects on overall tuberculosis (TB) immunity are unknown. We prepared M. tuberculosis-specific γ9δ2 T cell lines to study their direct protective effects and APC functions for M. tuberculosis-specific αβ T cells. The direct inhibitory effects on intracellular mycobacteria were measured, and the enhancing effects on proliferative and effector responses of αβ T cells assessed. Furthermore, the importance of cell-to-cell contact and soluble products for γ9δ2 T cell effector responses and APC functions were investigated. We demonstrate, in addition to direct inhibitory effects on intracellular mycobacteria, the following: (i) γ9δ2 T cells enhance the expansion of M. tuberculosis-specific αβ T cells and increase the ability of αβ T cells to inhibit intracellular mycobacteria; (ii) although soluble mediators are critical for the direct inhibitory effects of γ9δ2 T cells, their APC functions do not require soluble mediators; (iii) the APC functions of γ9δ2 T cells involve cell-to-cell contact that is dependent on CD40-CD40 ligand (CD40L) interactions; and (iv) fully activated CD4+ αβ T cells and γ9δ2 T cells provide similar immune enhancing/APC functions for M. tuberculosis-specific T cells. These effector and helper effects of γ9δ2 T cells further indicate that these T cells should be considered important new targets for new TB vaccines.
机译：包括结核分枝杆菌在内的许多病原体都可以激活人γ 9 δ 2 T细胞增殖并表达效应机制。 γ 9 δ 2 T细胞可直接抑制细胞内分枝杆菌的生长，也可作为抗原呈递细胞（APC）。尽管有证据表明γδT细胞具有充当APC的能力，但是这些作用对整体结核病（TB）免疫的影响机制和重要性尚不清楚。我们制备了结核分枝杆菌特异性γ 9 δ 2 T细胞系，以研究其对结核分枝杆菌特异性αβT细胞的直接保护作用和APC功能。测量对细胞内分枝杆菌的直接抑制作用，并评估对αβT细胞增殖和效应反应的增强作用。此外，研究了细胞间接触和可溶性产物对γ 9 δ 2 T细胞效应子反应和APC功能的重要性。除了对细胞内分枝杆菌的直接抑制作用外，我们还证明了以下几点：（i）γ 9 δ 2 T细胞增强结核分枝杆菌特异性αβT的扩增细胞并提高αβT细胞抑制细胞内分枝杆菌的能力; （ii）尽管可溶性介体对于γ 9 δ 2 T细胞的直接抑制作用至关重要，但其APC功能不需要可溶性介体; （iii）γ 9 δ 2 T细胞的APC功能涉及细胞间接触，这取决于CD40-CD40配体（CD40L）的相互作用; （iv）完全活化的CD4 + αβT细胞和γ 9 δ 2 T细胞为结核分枝杆菌提供相似的免疫增强/ APC功能特异性T细胞。 γ 9 δ 2 T细胞的这些效应和辅助作用进一步表明，应将这些T细胞视为新结核病疫苗的重要新靶标。

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