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首页> 外文期刊>Infection and immunity >Dietary Omega-3 Fatty Acids Increase Survival and Decrease Bacterial Load in Mice Subjected to Staphylococcus aureus-Induced Sepsis
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Dietary Omega-3 Fatty Acids Increase Survival and Decrease Bacterial Load in Mice Subjected to Staphylococcus aureus-Induced Sepsis

机译：饮食中的Omega-3脂肪酸可增加金黄色葡萄球菌诱导的败血症小鼠的存活率并降低其细菌负荷

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Sepsis caused by Staphylococcus aureus is increasing in incidence. With the alarming use of antibiotics, S. aureus is prone to become methicillin resistant. Antibiotics are the only widely used pharmacological treatment for sepsis. Interestingly, mice fed high-fat diet (HFD) rich in polyunsaturated fatty acids have better survival of S. aureus-induced sepsis than mice fed HFD rich in saturated fatty acids (HFD-S). To investigate what component of polyunsaturated fatty acids, i.e., omega-3 or omega-6 fatty acids, exerts beneficial effects on the survival of S. aureus-induced sepsis, mice were fed HFD rich in omega-3 or omega-6 fatty acids for 8 weeks prior to inoculation with S. aureus. Further, mice fed HFD-S were treated with omega-3 fatty acid metabolites known as resolvins. Mice fed HFD rich in omega-3 fatty acids had increased survival and decreased bacterial loads compared to those for mice fed HFD-S after S. aureus-induced sepsis. Furthermore, the bacterial load was decreased in resolvin-treated mice fed HFD-S after S. aureus-induced sepsis compared with that in mice treated with vehicle. Dietary omega-3 fatty acids increase the survival of S. aureus-induced sepsis by reversing the deleterious effect of HFD-S on mouse survival.
机译：由金黄色葡萄球菌引起的败血症的发病率正在增加。随着对抗生素的惊人使用，金黄色葡萄球菌易于对甲氧西林产生耐药性。抗生素是脓毒症唯一被广泛使用的药物治疗方法。有趣的是，饲喂富含多不饱和脂肪酸的高脂饮食（HFD）的小鼠比饲喂富含饱和脂肪酸（HFD-S）的小鼠具有更好的金黄色葡萄球菌诱导的败血症生存率。为了研究多不饱和脂肪酸（omega-3或omega-6脂肪酸）的哪些成分对金黄色葡萄球菌引起的败血症的存活具有有益作用，向小鼠喂食富含omega-3或omega-6脂肪酸的HFD接种金黄色葡萄球菌前先放置8周。此外，用已知为resolvins的omega-3脂肪酸代谢物处理喂食了HFD-S的小鼠。与在金黄色葡萄球菌诱导的败血症后喂食HFD-S的小鼠相比，喂食富含omega-3脂肪酸的HFD的小鼠具有更高的存活率和更低的细菌载量。此外，与用赋形剂处理的小鼠相比，在金黄色葡萄球菌诱导的败血症后用HFD-S喂养的用Resolvin处理的小鼠的细菌负荷降低。饮食中的omega-3脂肪酸可通过逆转HFD-S对小鼠存活的有害作用来增加金黄色葡萄球菌诱导的败血症的存活。

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