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Increased Chain Length Promotes Pneumococcal Adherence and Colonization

机译：链长增加促进肺炎球菌的粘附和定植

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Streptococcus pneumoniae is a mucosal pathogen that grows in chains of variable lengths. Short-chain forms are less likely to activate complement, and as a consequence they evade opsonophagocytic clearance more effectively during invasive disease. When grown in human nasal airway surface fluid, pneumococci exhibited both short- and long-chain forms. Here, we determined whether longer chains provide an advantage during colonization when the organism is attached to the epithelial surface. Chain-forming mutants and the parental strain grown under conditions to promote chain formation showed increased adherence to human epithelial cells (A549 cells) in vitro. Additionally, adherence to A549 cells selected for longer chains within the wild-type strain. In vivo in a murine model of colonization, chain-forming mutants outcompeted the parental strain. Together, our results demonstrate that morphological heterogeneity in the pneumococcus may promote colonization of the upper respiratory tract by enhancing the ability of the organism to bind to the epithelial surface.
机译：肺炎链球菌是一种粘膜病原体，以可变长度的链生长。短链形式不太可能激活补体，因此它们在浸润性疾病中更有效地逃避了调理吞噬作用的清除。当在人鼻气道表面液中生长时，肺炎球菌同时表现出短链和长链形式。在这里，我们确定了当生物体附着于上皮表面时，较长的链是否在定植期间提供了优势。链形成突变体和在促进链形成的条件下生长的亲本菌株在体外 对人上皮细胞（A549细胞）的粘附性增加。另外，对野生型菌株中较长链选择的A549细胞的粘附。 体内在鼠类定殖模型中，链形成突变体的竞争能力超过了亲本菌株。总之，我们的结果表明，肺炎球菌的形态异质性可能会通过增强生物体与上皮表面结合的能力来促进上呼吸道的定植。

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