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Host Response to Nontuberculous Mycobacterial Infections of Current Clinical Importance

机译：宿主对当前临床重要性的非结核分枝杆菌感染的反应

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The nontuberculous mycobacteria are a large group of acid-fast bacteria that are very widely distributed in the environment. While Mycobacterium avium was once regarded as innocuous, its high frequency as a cause of disseminated disease in HIV-positive individuals illustrated its potential as a pathogen. Much more recently, there is growing evidence that the incidence of M. avium and related nontuberculous species is increasing in immunocompetent individuals. The same has been observed for M. abscessus infections, which are very difficult to treat; accordingly, this review focuses primarily on these two important pathogens. Like the host response to M. tuberculosis infections, the host response to these infections is of the TH1 type but there are some subtle and as-yet-unexplained differences.
机译：非结核分枝杆菌是一大类耐酸细菌，它们广泛分布在环境中。虽然禽分枝杆菌曾经被认为是无害的，但其高频率是导致HIV阳性个体传播疾病的原因，说明了其作为病原体的潜力。最近，越来越多的证据表明，具有免疫能力的个体中鸟分枝杆菌和相关非结核物种的发生率正在增加。对于脓肿分枝杆菌感染也观察到了同样的情况，很难治疗。因此，本综述主要针对这两种重要的病原体。像宿主对结核分枝杆菌感染的反应一样，宿主对这些感染的反应也属于TH1类型，但仍存在一些细微且尚未解释的差异。

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