• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Infection and immunity >Mycobacterium tuberculosis Strains Lacking Surface Lipid Phthiocerol Dimycocerosate Are Susceptible to Killing by an Early Innate Host Response
【24h】

Mycobacterium tuberculosis Strains Lacking Surface Lipid Phthiocerol Dimycocerosate Are Susceptible to Killing by an Early Innate Host Response

机译：结核分枝杆菌菌株缺乏表面脂质硫代双酚双霉菌酸酯易被早期先天宿主反应杀死

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The innate immune response plays an important but unknown role in host defense against Mycobacterium tuberculosis. To define the function of innate immunity during tuberculosis, we evaluated M. tuberculosis replication dynamics during murine infection. Our data show that the early pulmonary innate immune response limits M. tuberculosis replication in a MyD88-dependent manner. Strikingly, we found that little M. tuberculosis cell death occurs during the first 2 weeks of infection. In contrast, M. tuberculosis cells deficient in the surface lipid phthiocerol dimycocerosate (PDIM) exhibited significant death rates, and consequently, total bacterial numbers were reduced. Host restriction of PDIM-deficient M. tuberculosis was not alleviated by the absence of interferon gamma (IFN-γ), inducible nitric oxide synthase (iNOS), or the phagocyte oxidase subunit p47. Taken together, these data indicate that PDIM protects M. tuberculosis from an early innate host response that is independent of IFN-γ, reactive nitrogen intermediates, and reactive oxygen species. By employing a pathogen replication tracking tool to evaluate M. tuberculosis replication and death during infection, we identify both host and pathogen factors affecting the outcome of infection.
机译：在抵抗结核分枝杆菌的宿主防御中，先天免疫应答起着重要但未知的作用。为了定义结核病中先天免疫的功能，我们评估了鼠感染期间结核分枝杆菌的复制动态。我们的数据表明，早期的肺先天免疫反应以MyD88依赖的方式限制了结核分枝杆菌的复制。令人惊讶的是，我们发现在感染的前2周内很少发生结核分枝杆菌细胞死亡。相反，缺乏表面脂质二硫代木蜡二椰菜酸酯（PDIM）的结核分枝杆菌细胞表现出显着的死亡率，因此总细菌数减少。缺乏干扰素γ（IFN-γ），诱导型一氧化氮合酶（iNOS）或吞噬细胞氧化酶亚基p47不能减轻PDIM缺陷型结核分枝杆菌的宿主限制。综上所述，这些数据表明PDIM保护结核分枝杆菌免受早期先天宿主反应，该反应独立于IFN-γ，反应性氮中间体和反应性氧种类。通过使用病原体复制跟踪工具评估结核分枝杆菌在感染过程中的复制和死亡，我们确定了影响感染结果的宿主和病原体因素。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号